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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones - Softcover
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We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits.
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Über die Autorin bzw. den Autor
Dr. Adil Mehraj Khan ist Assist. Prof. in Veterinärpharmakologie und -toxikologie an der SKUAST-K, Indien. Er schloss sein Postgraduiertenstudium an der SKUAST-J ab und promovierte an der GADVASU, Ludhiana. Er hat Forschungsarbeiten in angesehenen Fachzeitschriften veröffentlicht und ist außerdem regelmäßiger Gutachter und Mitglied des Redaktionsausschusses hochwertiger Fachzeitschriften.
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits. 164 pp. Englisch. Bestandsnummer des Verkäufers 9786138976462
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. We evaluated the fluoroquinolones levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxic. Bestandsnummer des Verkäufers 791057876
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model : Evaluation of Retinopathic Potential of Fluoroquinolones
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits. Bestandsnummer des Verkäufers 9786138976462
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model: Evaluation of Retinopathic Potential of Fluoroquinolones
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Retinopathic Potential of Fluoroquinolones Using Rabbit as Model
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -We evaluated the fluoroquinolones; levofloxacin, pazufloxacin and enrofloxacin for their retinopathic potential using rabbit as experimental model. Rabbits were gavaged individual fluoroquinolones alone and in combination with meloxicam for 21 days. Meloxicam was given, being an anti-inflammatory and usually being co-administered with antimicrobials, in various infections. Parameters of elimination kinetics and oxidative stress were calculated at different time points. The toxicokinetics of fluoroquinolones revealed that repeated administration produced a significant alteration in elimination phase parameters with no significant impact due to co-administration of meloxicam. Significant oxidative damage was produced in meloxicam, pazufloxacin and enrofloxacin treated groups. The histology of retina revealed severe retinal damage in enrofloxacin, moderate in pazufloxacin and mild damage in levofloxacin treated rabbits. The lesions included retinal pigment epithelium thinning, retinal detachment, neovascularization and formation of apoptotic bodies. Retinal ABCG-2 transporter protein had highest immunolocalization in enrofloxacin and lowest in the levofloxacin treated rabbits.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 164 pp. Englisch. Bestandsnummer des Verkäufers 9786138976462
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