Method Development & Validation of Diclofenac Sodium and Pantoprazole: Simultaneous Estimation in Bulk Dosage Form - Softcover

Chaki, Imran; Acharya, Hardik; Pujara, Naisarg

 
9786139460748: Method Development & Validation of Diclofenac Sodium and Pantoprazole: Simultaneous Estimation in Bulk Dosage Form
Softcover
ISBN 10: 6139460743 ISBN 13: 9786139460748
Verlag: LAP LAMBERT Academic Publishing, 2019

Inhaltsangabe

The present work describes various methods for the simultaneous estimation of Diclofenac sodium (DICLO) and Pantoprazole (PANTO) in combined Capsule dosage form. A simple, accurate and reproducible RP-HPLC method have been developed and validated for the simultaneous estimation of Diclofenac sodium and Pantoprazole in their marketed formulation. The RP-HPLC methods were validated by Stastically. The retention times of Diclofenac sodium and Pantoprazole were found to be 3.33 ± 0.10 min and 6.66 ± 0.10 min, respectively. Linearity was evaluated over the concentration range of 18.75-56.25 µg/ml for DICLO and 5-15 µg/ml for PANTO by RP-HPLC method. The correlation coefficient and accuracy of both the methods were found to be within the range. The % RSD of precision was found to be NMT 2.0 % for HPLC method. The proposed methods were found to be robust when slight but deliberate changes were made in analytical conditions. Simple, accurate and reproducible RP-HPLC method were developed and validated for the simultaneous estimation of Diclofenac sodium and Pantoprazole in their marketed formulation. The proposed methods can be applied for the routine analysis in quality control laboratory.

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Über die Autorin bzw. den Autor

Imran A. Chaki, Master of Pharmacy, Pharmaceutical Quality Assurance from Gujarat Technological University. Research Associate at Quantys Clinical Private Limited in Quality Assurance Department.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2019
Sprache
Englisch
ISBN 10 
6139460743
ISBN 13 
9786139460748
Einband
Taschenbuch
Anzahl der Seiten
120
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Editions Vie
customerservice@vdm-vsg.de

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Riga
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