Effect of CoCl2 in vascular dysfunction of diabetic nephropathy - Softcover

Deshmukh, Aaishwarya; Patel, Jayvadan

 
9786139927982: Effect of CoCl2 in vascular dysfunction of diabetic nephropathy
Softcover
ISBN 10: 6139927986 ISBN 13: 9786139927982
Verlag: LAP LAMBERT Academic Publishing, 2018

Inhaltsangabe

A variety of human disorders are characterized by, or associated with, tissue hypoxia and manipulation of the HIF pathway has been predicted to significantly alter their clinical course. Early hopes of developing revolutionary PHD-based therapies have yet to translate into novel licensed pharmaceutical agents. Diabetic nephropathy, a progressive development of renal insufficiency in the setting of hyperglycaemia is the major single cause of chronic renal failure (CRF) in which hypoxia plays a critical role. The study investigated the efficacy of cobalt chloride (CoCl2), a Prolyl 4-hydroxylase (PHD) inhibitor in amelioration of renal injury, endothelial dysfunction as well as its effect on hyperglycemia in uninephrectomized diabetic rat. The study signifies the effect of CoCl2 in amelioration of renal failure and associated vascular dysfunctuion.

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Über die Autorin bzw. den Autor

Dr. Aaishwarya B. Deshmukh is having experience of 11+ years in pharmaceutical R&D and Academics. She has also served as executive scientist at Torrent research centre, Project coordinator at Dishman Pharmaceuticals ltd and has 20 research publications and 05 book chapters. She has presented papers in many national and international conferences.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2018
Sprache
Englisch
ISBN 10 
6139927986
ISBN 13 
9786139927982
Einband
Taschenbuch
Anzahl der Seiten
252
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
SIA OmniScriptum Publishing
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
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Lettland