Structure Activity Relationship of Drugs of Abuse: Synthetic Cannabinoids, Synthetic Cathinones and Fentanyl analogues - Softcover

Axisa, Kersty; Vella Szijj, Janis; Serracino Inglott, Anthony

 
9786139932672: Structure Activity Relationship of Drugs of Abuse: Synthetic Cannabinoids, Synthetic Cathinones and Fentanyl analogues
Softcover
ISBN 10: 613993267X ISBN 13: 9786139932672
Verlag: LAP LAMBERT Academic Publishing, 2018

Inhaltsangabe

Structures of novel psychoactive substances are based on the structure activity relationship (SAR) of existing drugs of abuse. The study identified links between structural modifications and toxicities, adverse and physiological effects of cannabinoids, cathinones and opioids. Literature review identified the structural backbone, toxicities, adverse and physiological effects of cannabinoids, cathinones and opioids. SAR of cannabinoids, cathinones and opioids was based on amino alkylindoles, cathinone derivatives and fentanyl derivatives. Synthetic cannabinoids XLR-11 and MDMB-CHMICA have been linked to acute kidney injury due to over stimulation of CB1 receptors. The synthetic cathinones MDPV and ¿-PVP cause a higher occurrence of psychosis and delirium compared to other synthetic cathinones due to inhibitory uptake effects at dopamine and norepinephrine transporters. Fentanyl analogues having a lower lipophilic value than fentanyl had a shorter duration of physiological effects compared to fentanyl analogues having higher lipophilic values than fentanyl. The study contributes to an explanation of the higher potencies, toxicities and adverse effects associated with synthetic drugs.

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Über die Autorin bzw. den Autor

Kersty Axisa is a pharmaceutical technology graduate who is currently undertaking an International Fellowship programme with the Advanced Scientific Initiative directorate at the Malta Medicines Authority. Kersty is planning to start a Master of Science in Pharmacy to broaden her knowledge and research capabilities in the area of drugs of abuse.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2018
Sprache
Englisch
ISBN 10 
613993267X
ISBN 13 
9786139932672
Einband
Taschenbuch
Anzahl der Seiten
268
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Fastbook Publishing
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
Lettland