Drug lead identification using molecular docking approach: Case study - Softcover

Narayanaswamy, Radhakrishnan

Softcover

ISBN 10: 6139967759 ISBN 13: 9786139967759

Verlag: LAP LAMBERT Academic Publishing, 2018

Inhaltsangabe

Molecular docking is a computational method to study the formation of intermolecular complexes of one small molecule ligand (drug lead) with a macromolecule, which usually is a protein (drug target) of known three dimensional structure. Four different types of interactions between the molecules can be distinguished such as 1) protein-protein; 2) protein-DNA; 3) DNA-ligand and 4) protein-ligand. In recent years, the availability of three dimensional (3D) structures for many macromolecular drug targets (proteins) and rapid advancement in computational chemistry and bioinformatics, both in vitro and in silico serve a new novel platform for the development as well as exploring modern computational methods. When the 3 D structure of the macromolecular target is known, then the design of the computational library can be customized to suit the geometry of the binding site. Moreover, identifying binding sites and protein-ligand interactions using bioinformatics tools before venturing into wet laboratory studies saves the energy, time and money considerably.

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Über die Autorin bzw. den Autor

Dr. Radhakrishnan Narayanaswamy is currently working as Associate Professor (Department of Biotechnology) and facilitator for Bio Incubator, Vel Tech Technology Incubator, Vel Tech Rangarajan Dr. Sagunthala R & D Institute of Science and Technology, Avadi, Chennai, Tamil Nadu State, India.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2018
• Sprache: Englisch
• ISBN 10: 6139967759
• ISBN 13: 9786139967759
• Einband: Taschenbuch
• Anzahl der Seiten: 60
• Kontakt zum Hersteller: Nicht verfügbar
• Verantwortliche Person: SIA OmniScriptum Publishing; customerservice@vdm-vsg.de; ; Brivibas gatve 197; Riga; 1039; Lettland