Verwandte Artikel zu A Novel Synthesis Of Isotopically Labelled L-Histidine

A Novel Synthesis Of Isotopically Labelled L-Histidine - Softcover

Talab, Sarra

 
9786139984787: A Novel Synthesis Of Isotopically Labelled L-Histidine
Softcover
ISBN 10: 6139984785 ISBN 13: 9786139984787
Verlag: LAP LAMBERT Academic Publishing, 2018

Inhaltsangabe

In a few simple steps starting from a commercially available reagents benzyl chloride and potassium thiocyanate, thiocyanate is obtained which is directly reacted with glycine amide to give benzyl thiourea. The used of concentrated HCl give the ring closed product of the latter. The alkylation of 3-benzyl-2- thioxoimidazolidin-4-one is made by the used of methyl iodide under basic condition. Subsequent treatment of the alkyl derivative 3-benzyl-2-(methylthio)-3,5dihydro-4-imidazole with diethyl phosphono cyanate gives the nitrile derivatives which upon treatment with sulphuric acid and functional group manipulations gave 1-benzyl-5-chloromethylimidazolium chloride. This compound is converted mildly under O'Donnell conditions into the l- Histidine derivative. After deprotection L-Histidine is obtained in good yield with 99% enantiomeric excess. This synthetic scheme allows access to any isotopomer of L-histidine and many other biologically important imidazole derivatives.

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Über die Autorin bzw. den Autor

Assistant professor Organic chemistry,Chemistry Department, Collage of Science, Al Imam Mohammad Ibn Saud Isalmic University Riyadh Saudi Arabia

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2018
Sprache
Englisch
ISBN 10 
6139984785
ISBN 13 
9786139984787
Einband
Taschenbuch
Anzahl der Seiten
120
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
SIA OmniScriptum Publishing
customerservice@vdm-vsg.de

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Riga
1039
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