Synthesis & Study Biological Activity of New Phthalimide Derivatives: Study the biological activity of new Mannich bases derived from phthalimide - Softcover

Hashim, Asaad; Musa, Naji; Radhi, Rua

 
9786200499684: Synthesis & Study Biological Activity of New Phthalimide Derivatives: Study the biological activity of new Mannich bases derived from phthalimide
Softcover
ISBN 10: 6200499683 ISBN 13: 9786200499684
Verlag: LAP LAMBERT Academic Publishing, 2019

Inhaltsangabe

The research involves synthesis of some new aminoacetylenic derivatives of phthalimide. The phthalimide in this study served as starting material and was converted to the corresponding potassium salt through reaction with potassium hydroxide. The alkylation of the imide salt with the propargyl bromide afforded the desired N-propynylphthalimide (A1). The Mannich reaction (three componenets in one pot reaction) was carried out by using the N-propynylphthalimide (A1), formaldehyde, benzaldehyde and some of its derivatives, as well as morpholine or piperidine which are taken as secondary amines, in the presence of peroxide free dioxane and a catalytic amount of cuprous chloride under various basic, acidic, solvent and temperature conditions, resulted in formation of a novel aminoacetylenic Isoindoline-1,3-dione derivatives (A2-A12).

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Über die Autorin bzw. den Autor

Asaad Hashim received BSc degree in Chemistry in 2002 and MSc in Chemistry in 2012. ¿urrently he is a PhD student.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2019
Sprache
Englisch
ISBN 10 
6200499683
ISBN 13 
9786200499684
Einband
Taschenbuch
Anzahl der Seiten
92
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
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