Formulation and Evaluation of Fast Dissolving Tablet of Clopidogrel: Fast Dissolving Tablets - Softcover

Pandit, Vinay; Ashawat, M. S.; Dutta, Surbhi

 
9786200535078: Formulation and Evaluation of Fast Dissolving Tablet of Clopidogrel: Fast Dissolving Tablets
Softcover
ISBN 10: 6200535078 ISBN 13: 9786200535078
Verlag: LAP LAMBERT Academic Publishing, 2020

Inhaltsangabe

The present investigation involves formulation and evaluation of fast dissolving tablet of clopidogrel, which is used to prevent coronary disorder. Platelet aggregation is part of the sequence events leading to the formulation of a thrombus (clot). Antiplatelet therapy with one or more drugs decreases the ability of blood clot to form by interfering with the platelet activation process in primary homeostasis. Tablets were formulated by three different methods Viz., Direct compression method, Solid dispersion method and Sublimation method. Different excipients such as, crospovidone as super disintegrants, croscarmellose as superdisintegrant, magnesium stearate as lubricant, talc as glidant etc. were used. Based on in-vitro release studies tablets prepared by sublimation method clopidogrel was selected as optimizes formulation. In-vitro release studies indicated more than 95% release of drug in 30 mins. The accurate stability studies indicated no change in in-vitro release and other property of the tablet. Thus sublimation method can be a promising strategy in enhancing the solubility and dissolution studies of clopidogrel bisulphate.

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Über die Autorin bzw. den Autor

Dr. Vinay Pandit is working as Professor and Head, Department of Pharmaceutics, Laureate Institute of Pharmacy, Kathog, Jawlamukhi, Himachal Pradesh. He has published a number of research articles in various reputed journals nationally and internationally. His area of research is fast dissolving technology and chronotherapeutics.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2020
Sprache
Englisch
ISBN 10 
6200535078
ISBN 13 
9786200535078
Einband
Taschenbuch
Anzahl der Seiten
108
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Edicoes Nosso Conhecimento
customerservice@vdm-vsg.de

SIA
Riga
1039
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