Abstract To analyze the frequency of polymorphic variants of genes BCL-2, CTLA-4, APO-1 / Fas in patients with thyroid pathology regarding its forms: nodular goiter with autoimmune thyroiditis and thyroid adenoma. Results: Mutation of BCL-2 and CTLA-4 genes in the homozygous state among resident’s adult population of Northern Bukovina occurs with a fre-quency 3,2-4,0%, no reliable difference between patients and healthy. Muta-tions of the gene APO-1 / Fas in the homozygous state are not observed. The nature of allelic distribution set: parity ratio between the main A and G minor alleles of the BCL-2 gene. A dominance of wild-allele mutation of the G-allele CTLA-4 gene 2.57 times among patients, and 3.54 times among healthy; and the prevalence of G-allele mutation of the A-allele gene Fas – 9.87 times in pa-tients and 7.33 times – in healthy. Conclusions: Pathology of the thyroid gland in general has unreliable chances to be inherited depending on the polymorphism of BCL-2, CTLA-4 and Fas genes in Bukovina (Western Ukraine).
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Chirurgische Abteilung, ¿1 der Bukowiner Staatlichen Medizinischen Universität. Michael Ivanovich Sheremet, PhD, Assistenzprofessor; Volodymyr Volodymyrovich Tarabanchuk, PhD, Assistenzprofessor;Vitaliy Vasilyovich Maksymyuk, MD, PhD, Professor.
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Abstract To analyze the frequency of polymorphic variants of genes BCL-2, CTLA-4, APO-1 / Fas in patients with thyroid pathology regarding its forms: nodular goiter with autoimmune thyroiditis and thyroid adenoma. Results: Mutation of BCL-2 and CTLA-4 genes in the homozygous state among resident's adult population of Northern Bukovina occurs with a fre-quency 3,2-4,0%, no reliable difference between patients and healthy. Muta-tions of the gene APO-1 / Fas in the homozygous state are not observed. The nature of allelic distribution set: parity ratio between the main A and G minor alleles of the BCL-2 gene. A dominance of wild-allele mutation of the G-allele CTLA-4 gene 2.57 times among patients, and 3.54 times among healthy; and the prevalence of G-allele mutation of the A-allele gene Fas - 9.87 times in pa-tients and 7.33 times - in healthy. Conclusions: Pathology of the thyroid gland in general has unreliable chances to be inherited depending on the polymorphism of BCL-2, CTLA-4 and Fas genes in Bukovina (Western Ukraine). 64 pp. Englisch. Bestandsnummer des Verkäufers 9786202027199
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Zustand: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Sheremet MichaelIn 2006 he defended his Ph.D. thesis Complex treatment of nodular forms of goiter and prevention of postoperative complications . In 2016 he planned his doctoral dissertation on the theme Autoimmune thyroiditis: pat. Bestandsnummer des Verkäufers 166830341
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Abstract To analyze the frequency of polymorphic variants of genes BCL-2, CTLA-4, APO-1 / Fas in patients with thyroid pathology regarding its forms: nodular goiter with autoimmune thyroiditis and thyroid adenoma. Results: Mutation of BCL-2 and CTLA-4 genes in the homozygous state among resident's adult population of Northern Bukovina occurs with a fre-quency 3,2-4,0%, no reliable difference between patients and healthy. Muta-tions of the gene APO-1 / Fas in the homozygous state are not observed. The nature of allelic distribution set: parity ratio between the main A and G minor alleles of the BCL-2 gene. A dominance of wild-allele mutation of the G-allele CTLA-4 gene 2.57 times among patients, and 3.54 times among healthy; and the prevalence of G-allele mutation of the A-allele gene Fas - 9.87 times in pa-tients and 7.33 times - in healthy. Conclusions: Pathology of the thyroid gland in general has unreliable chances to be inherited depending on the polymorphism of BCL-2, CTLA-4 and Fas genes in Bukovina (Western Ukraine). Bestandsnummer des Verkäufers 9786202027199
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Abstract To analyze the frequency of polymorphic variants of genes BCL-2, CTLA-4, APO-1 / Fas in patients with thyroid pathology regarding its forms: nodular goiter with autoimmune thyroiditis and thyroid adenoma. Results: Mutation of BCL-2 and CTLA-4 genes in the homozygous state among resident's adult population of Northern Bukovina occurs with a fre-quency 3,2-4,0%, no reliable difference between patients and healthy. Muta-tions of the gene APO-1 / Fas in the homozygous state are not observed. The nature of allelic distribution set: parity ratio between the main A and G minor alleles of the BCL-2 gene. A dominance of wild-allele mutation of the G-allele CTLA-4 gene 2.57 times among patients, and 3.54 times among healthy; and the prevalence of G-allele mutation of the A-allele gene Fas - 9.87 times in pa-tients and 7.33 times - in healthy. Conclusions: Pathology of the thyroid gland in general has unreliable chances to be inherited depending on the polymorphism of BCL-2, CTLA-4 and Fas genes in Bukovina (Western Ukraine).VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 64 pp. Englisch. Bestandsnummer des Verkäufers 9786202027199
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Taschenbuch. Zustand: Neu. Nodular forms of goiter with autoimmune thyroiditis, thyroid adenoma | Polymorphic variants of genes BCL-2, CTLA-4, APO-1 / Fas in patients with thyroid pathology regarding its forms. | Michael Sheremet (u. a.) | Taschenbuch | 64 S. | Englisch | 2017 | LAP LAMBERT Academic Publishing | EAN 9786202027199 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 109687414
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