Formulation & Development of Lamotrigine Orodispersible Tablet: Liquisolid Technology - Softcover

Shah, Rumit; Patel, Bhumit

Softcover

ISBN 10: 6202028262 ISBN 13: 9786202028264

Verlag: LAP LAMBERT Academic Publishing, 2022

Inhaltsangabe

Lamotrigine comes under the category of anti-epileptic drug. It is a BCS class II drug which is insoluble in water and its half-life is 24-25 hours with 90% bioavailability. To obtain an enhanced in-vitro dissolution rate of Lamotrigine by using Liquisolid technique and Liquisolid tablets were optimized by QbD-DoE approach 32 full factorial design using Design Expert Software. All prepared liquisolid batches were subjected to weight variation, drug content uniformity, hardness, friability test, and disintegration test and dissolution tests. Liquisolid systems were also tested for DSC, FT-IR. From result of check point analysis of design data, LMLCODT1 shows higher Drug release at LAMOTRIGINE less wetting time and disintegrating time (5.24 sec) which enhancing solubility of Lamotrigine by 4.73 mg/ml. Hence, this research work may be useful to formulate Orodispersible Tablets using Liquisolid Technique which may give rapid onset of action by rapid absorption, maximize efficacy, reduce dose and dose frequency & hence increase patient Compliance.

Über diesen Titel

Über die Autorin bzw. den Autor

Dr. Rumit M. Shah is working as Associate Professor at Shree Naranajibhai Lalbhai Patel College of Pharmacy, Bardoli, Surat Gujarat, since 2009. He has published many national and international papers and actively participate in various seminars and conferences

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2022
• Sprache: Englisch
• ISBN 10: 6202028262
• ISBN 13: 9786202028264
• Einband: Taschenbuch
• Anzahl der Seiten: 164
• Kontakt zum Hersteller: Nicht verfügbar
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