Method development using Back-Scattering Interferometry: Analysis of binding between the adenosine A2A receptor and three selective antagonists - Softcover

Schaffrath, Bianca

Softcover

ISBN 10: 6202200804 ISBN 13: 9786202200806

Verlag: AV Akademikerverlag, 2017

Inhaltsangabe

Back-scattering interferometry is one of the latest technologies for the study and characterization of interactions between small molecules and more complex drug targets in a native-like environment without any labels or tethers. The information obtained with this technique is of great value since the conditions for the measurement are closest to the real conditions in the body. Principle of signal generation are conformational changes that occur during a binding event between a drug target and its ligand. In this project, the binding interaction between the adenosine A2A receptor and the three antagonists ZM 241385, SCH 58251 and XAC, as well as the agonist (CGS 21680) as positive control was examined. The knowledge about the interactions of the A2AR and its antagonists is of high interest for research of neurological disorders like Parkinson’s disease.

Über diesen Titel

Über die Autorin bzw. den Autor

Bianca Schaffrath, MSc:Bio and Pharmaceutical Analysis, Master of Science at Hochschule Fresenius Idstein,Applied Chemistry, Bachelor of Science at Hochschule Fresenius Idstein,practical vocational semester at Nottingham Trent University, Nottingham.

Details zur Ausgabe

• Verlag: AV Akademikerverlag
• Erscheinungsdatum: 2017
• Sprache: Englisch
• ISBN 10: 6202200804
• ISBN 13: 9786202200806
• Einband: Taschenbuch
• Anzahl der Seiten: 140
• Kontakt zum Hersteller: Nicht verfügbar
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