Pyrazoles: Synthesis and Biological Activity: Pyrazoles - Softcover

Gomha, Sobhi; Abdallah, Magda A.; Abbas, Ikhlass M.

 
9786202525305: Pyrazoles: Synthesis and Biological Activity: Pyrazoles
Softcover
ISBN 10: 6202525304 ISBN 13: 9786202525305
Verlag: LAP LAMBERT Academic Publishing, 2020

Inhaltsangabe

The original work of the present book consists of three research projects: In the first part: Synthesis, cytotoxicity evaluation, molecular docking and utility of novel chalcones as precursors for heterocycles incorporating pyrazole moiety.In the second part: Synthesis and antimicrobial activity of novel azolopyrimidines and pyrido-triazolo-pyrimidinones incorporating pyrazole moiety.In the third part: Synthesis of new pyrazolyl-pyridines as antitumor agents. The assigned structures for all the newly synthesized compounds were confirmed on the basis of elemental analyses and spectral data and the mechanisms of their formation were also discussed. In addition, some of the newly synthesized chalcones were tested for their cytotoxicity against human colon carcinoma cell line (HCT-116) and against human hepatocellular carcinoma (HEPG2) cell lines and the results revealed that some compounds have promising activities compared with the standard drug Doxorubicin. Molecular docking was also carried out for the high potent compounds.

Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.

Über die Autorin bzw. den Autor

Prof. Sobhi Gomha was graduated from Cairo University, Egypt in 1995 then he appointed as a full Professor of Organic chemistry. He has published 166 scientific papers and reviews in the fields of synthetic organic chemistry, the chemistry of hydrazonoyl halides, the chemistry of enaminones, green chemistry and bioactive heterocyclic chemistry.

„Über diesen Titel“ kann sich auf eine andere Ausgabe dieses Titels beziehen.

Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2020
Sprache
Englisch
ISBN 10 
6202525304
ISBN 13 
9786202525305
Einband
Taschenbuch
Anzahl der Seiten
180
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
SIA OmniScriptum Publishing
customerservice@vdm-vsg.de

Brivibas gatve 197
Riga
1039
Lettland