The Use of Chemically Modified and Optimized Starches in Drug Delivery: Preparation, Optimization and Evaluation of Epichlorohydrincross-Linked Enset [Ensete Ventricosum (Welw.) Cheesman]) St - Softcover

Tesfay, Desta

 
9786202528818: The Use of Chemically Modified and Optimized Starches in Drug Delivery: Preparation, Optimization and Evaluation of Epichlorohydrincross-Linked Enset [Ensete Ventricosum (Welw.) Cheesman]) St
Softcover
ISBN 10: 6202528818 ISBN 13: 9786202528818
Verlag: LAP LAMBERT Academic Publishing, 2020

Inhaltsangabe

Ensete ventricosum (Welw.) cheeseman which belongs to the family of Musaceae is one of the main sources of starch in Ethiopia. This study aimed at evaluating epichlorohydrin cross-linked enset starch as a drug release sustaining excipient in microsphere formulations of theophylline. Extracted Enset starch was cross-linked using epichlorohydrin as a cross-linking agent. The effect of cross- linker concentration, cross-linking duration and cross- linking temperature on the degree of cross- linking and release rate of microspheres prepared by emulsion solvent evaporation method was investigated using two-level full factorial design. Accordingly, the concentration of epichlorohydrin and duration of cross-linking were the most significant factors affecting both the degree of cross-linking and drug release rate. Thus, the effects of these two factors were further studied and optimized using the central composite design. As per the numerical method of central composite design, the optimal points were obtained at epichlorohydrin concentration of 13.70% and cross-linking time of 3.82h. Under these optimal conditions, the model predicts the degree of cross-linking of 74.70% and drug release

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Über die Autorin bzw. den Autor

I am called Desta Tesfay Mezgebo. I am a senior pharmacist and lecturer of pharmaceutics with the experience of working in teaching hospital, participating and coordinating different team works and conferences, teaching, conducting different researches and as head department of pharmacy at the Department of Pharmacy, College of Medicine and Health

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2020
Sprache
Englisch
ISBN 10 
6202528818
ISBN 13 
9786202528818
Einband
Taschenbuch
Anzahl der Seiten
52
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
JustFiction Edition
customerservice@vdm-vsg.de

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Riga
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