Pharmacokinetic study of solid dispersion tablet of Kariyat extract: Pharmacokinetic, tissue distribution and stability study of solid dispersion tablet of Adrographis paniculata extract - Softcover

Nitave, Sachin Annasaheb; Koumaravelou, Kailasam; Patil, Vishin Ashish

 
9786205487143: Pharmacokinetic study of solid dispersion tablet of Kariyat extract: Pharmacokinetic, tissue distribution and stability study of solid dispersion tablet of Adrographis paniculata extract
Softcover
ISBN 10: 6205487144 ISBN 13: 9786205487143
Verlag: LAP LAMBERT Academic Publishing, 2022

Inhaltsangabe

Andrographolide is poorly soluble in water, it has low oral bioavailability. Objective of present study was to enhance solubility of andrographolide through solid dispersion technique and conversion it into tablet dosage form. Solubility of extract was found to be more from solid dispersion prepared by using Soluplus than that of prepared using PEG 6000. Compatibility study using IR, DSC and XRD showed that, ethanolic extract is compatible with soluplus and can be used for preparation of stable formulation. Pharmacokinetic study showed that, there was a significant increase in absorption of andrographolide from solid dispersion tablet. andrographolide. The relative bioavailability of andrographolide from solid dispersion tablet to that of pure andrographolide was found to be 177.59±14.6%. From tissue distribution study it can be concluded that, concentration of andrographolide in all tissues get increased in animals in which solid dispersion tablet was administered orally. It reveals that absorption of andrographolide is getting increased after conversion of extract into solid dispersion tablet. Accelerated stability study indicates that prepared solid dispersion was stable.

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Über die Autorin bzw. den Autor

O Dr. Sachin Annasaheb Nitave trabalha como director no Anil Alias Pintu Magdum Memorial Pharmacy College do Dr. J. J. Magdum Trust, em Dharangutti, Tal-Shirol, Dist-Kolhapur, Maharashtra, Índia. Obteve o primeiro lugar no exame M. Pharm da Universidade Shivaji. Publicou 63 artigos em diferentes revistas. Participou em mais de 50 acções de formação.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2022
Sprache
Englisch
ISBN 10 
6205487144
ISBN 13 
9786205487143
Einband
Taschenbuch
Anzahl der Seiten
68
Kontakt zum Hersteller
Nicht verfügbar
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