Computational Study of Quinoline-4-carboxylic acid and application - Softcover

Patel, Dhaval B.; Patel, Siddharth S.; Patel, Hitesh D.

 
9786206149057: Computational Study of Quinoline-4-carboxylic acid and application
Softcover
ISBN 10: 6206149056 ISBN 13: 9786206149057
Verlag: LAP LAMBERT Academic Publishing, 2023

Inhaltsangabe

Novel fluorine containing quinoline hybrid thiosemicarbazide analogues and screened for their in-vitrostudy in antibacterial, antifungal, antimalarial, antituberculosis strains. Analogues were active against antimalarial Plasmodium falciparum strain, among them analogues 8d, 8g, 8h, 8k and 8l shown remarkable activity than reference drug Quinine. We have carried out Molecular docking, ADME-Tox, Molecular dynamics and Pharmacophore study. Biological activity and Molecular docking study were correlated for the potent molecules. This study were suggested active binding site of analogues to give a best mechanism in in-silico side. Then, most active molecule 8g was performed for the molecular dynamics study. Here, this article concluded that analogues 8d, 8g and 8k were representing a promising lead for the new development of antimalarial therapeutics.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2023
Sprache
Englisch
ISBN 10 
6206149056
ISBN 13 
9786206149057
Einband
Tapa blanda
Anzahl der Seiten
76
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