Formulation and Evaluation of Propranolol Hydrochloride Floating Beads - Softcover

Gonugunta, Chandra Sekhara Rao; Yarguntla, Srinivasa Rao

Softcover

ISBN 10: 6206181588 ISBN 13: 9786206181583

Verlag: LAP LAMBERT Academic Publishing, 2023

Inhaltsangabe

The objective of the present study was to develop floating alginate beads of Propranolol hydrochloride for oral use with a point of view to treat hypertension. Propranolol is retained in the stomach for a prolonged period of time. The drug is stable and easily absorbable in an acidic medium. Its elimination half-life is about 3-6 hrs and its bioavailability is up to 25 %. Among the various approaches to achieve gastric retention time, the gastric floating drug delivery system is one approach selected to prolong the floating behavior of the alginate beads. For this purpose sodium alginate was used as a matrix bead forming agent, mineral oil as buoyancy imparting agent, and hydrophilic swellable polymers like HPMC K100, Eudragit S-100, Agar, Starch, and SSG were used as key ingredients to achieve the objective.

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O Dr. G. Chandra Sekhara Rao trabalha como professor de Farmácia no Instituto Vignan de Tecnologia Farmacêutica, Visakhapatnam, Andhra Pradesh, Índia. Tem cerca de 26 anos de experiência de ensino e investigação. Publicou 50 trabalhos de investigação em várias revistas nacionais e internacionais. Tem uma patente.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2023
• Sprache: Englisch
• ISBN 10: 6206181588
• ISBN 13: 9786206181583
• Einband: Taschenbuch
• Anzahl der Seiten: 52
• Kontakt zum Hersteller: Nicht verfügbar
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