Design, Development of Nitrendipin Self-Microemulsifying Drug Delivery: Nitrendipin Self-Microemulsifying Drug Delivery System - Softcover

Shinde, Anilkumar; More, Harinath; Jarag, Ravindra

 
9786207448104: Design, Development of Nitrendipin Self-Microemulsifying Drug Delivery: Nitrendipin Self-Microemulsifying Drug Delivery System
Softcover
ISBN 10: 6207448103 ISBN 13: 9786207448104
Verlag: LAP LAMBERT Academic Publishing, 2023

Inhaltsangabe

Self-microemulsifying drug delivery system (SMEDDS) of Nitrendipine was aimed at overcoming the problems of poor solubility and bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Ethyl oleate as oil, Cremophore RH40 as surfactant and PEG 400 as co-surfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size, zeta potential, self micro emulsification time and drug content determination. The optimized formulation exhibited 98 % in vitro drug release, which was significantly higher than that of the drug solution. Infrared spectroscopy, differential scanning calorimetric, SEM and x-ray diffraction studies indicated no incompatibility between drug, oil and surfactants. From the stability studies of solid SMEDDS, there was no significant decrease in drug release and drug content, hence the formulation is found to be stable and then Comparative in vitro release study of optimised batch.

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Über die Autorin bzw. den Autor

Dr. Anilkumar J. Shinde, M.Pharm Ph.D (Pharmacy) from Shivaji University, Kolhapur. He has 26 years experience in marketing, teaching & researching. Presently he is working as Associate Professor in Pharmaceutics Department at Bharati Vidyapeeth College of Pharmacy, Kolhapur. He has 64 research papers & 5 review articles & 2 patents published.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2023
Sprache
Englisch
ISBN 10 
6207448103
ISBN 13 
9786207448104
Einband
Taschenbuch
Anzahl der Seiten
52
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
JustFiction Edition
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