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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques - Softcover
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Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 μg/ml) limits its bioavailability. This study aimed to improve Irbesartan’s solubility through solid dispersions using carriers like β-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. β-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug’s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that β-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using β-cyclodextrin in solid dispersions effectively enhances Irbesartan’s solubility and therapeutic potential in treating hypertension.
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Enhancing Irbesartan Bioavailability via Solid Dispersion
Verlag:
LAP LAMBERT Academic Publishing Sep 2024, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Neu
Taschenbuch
Anbieter: buchversandmimpf2000, Emtmannsberg, BAYE, Deutschland
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Taschenbuch. Zustand: Neu. Neuware -Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 ¿g/ml) limits its bioavailability. This study aimed to improve Irbesartan¿s solubility through solid dispersions using carriers like ¿-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. ¿-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug¿s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that ¿-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using ¿-cyclodextrin in solid dispersions effectively enhances Irbesartan¿s solubility and therapeutic potential in treating hypertension.Books on Demand GmbH, Überseering 33, 22297 Hamburg 84 pp. Englisch. Bestandsnummer des Verkäufers 9786208119713
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Enhancing Irbesartan Bioavailability via Solid Dispersion
Verlag:
LAP LAMBERT Academic Publishing Sep 2024, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Neu
Taschenbuch
Anbieter: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Deutschland
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 84 pp. Englisch. Bestandsnummer des Verkäufers 9786208119713
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Enhancing Irbesartan Bioavailability via Solid Dispersion : Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Verlag:
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Neu
Taschenbuch
Anbieter: AHA-BUCH GmbH, Einbeck, Deutschland
Verkäuferbewertung 5 von 5 Sternen
Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 ¿g/ml) limits its bioavailability. This study aimed to improve Irbesartan¿s solubility through solid dispersions using carriers like ¿-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. ¿-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug¿s transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that ¿-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using ¿-cyclodextrin in solid dispersions effectively enhances Irbesartan¿s solubility and therapeutic potential in treating hypertension. Bestandsnummer des Verkäufers 9786208119713
Anzahl: 1 verfügbar
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Verlag:
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Neu
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Verlag:
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Neu
Softcover
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Verlag:
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Verlag:
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
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Enhancing Irbesartan Bioavailability via Solid Dispersion: Optimizing Dissolution of Irbesartan Through Advanced Solid Dispersion Techniques
Verlag:
LAP LAMBERT Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
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Enhancing Irbesartan Bioavailability via Solid Dispersion (Paperback)
Verlag:
LAP Lambert Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
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Paperback
Anbieter: AussieBookSeller, Truganina, VIC, Australien
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Paperback. Zustand: new. Paperback. Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 mg/ml) limits its bioavailability. This study aimed to improve Irbesartan's solubility through solid dispersions using carriers like b-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. b-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug's transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that b-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using b-cyclodextrin in solid dispersions effectively enhances Irbesartan's solubility and therapeutic potential in treating hypertension. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability. Bestandsnummer des Verkäufers 9786208119713
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Enhancing Irbesartan Bioavailability via Solid Dispersion (Paperback)
Verlag:
LAP Lambert Academic Publishing, 2024
ISBN 10: 6208119715
ISBN 13: 9786208119713
Neu
Paperback
Anbieter: CitiRetail, Stevenage, Vereinigtes Königreich
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Paperback. Zustand: new. Paperback. Hypertension is a prevalent condition, especially in those over 50, and can lead to severe cardiovascular complications. Irbesartan, an angiotensin II receptor blocker (ARB), is commonly used to manage hypertension, but its low aqueous solubility (1 mg/ml) limits its bioavailability. This study aimed to improve Irbesartan's solubility through solid dispersions using carriers like b-cyclodextrin, HPMC K4M, PEG4000, and Gelatin. b-cyclodextrin showed the greatest enhancement in solubility, as confirmed by phase solubility studies. Characterization through DSC and SEM indicated the drug's transformation from crystalline to amorphous form, improving dissolution. FTIR studies confirmed no interaction between the drug and carriers. In vitro dissolution tests revealed that b-cyclodextrin (1:9) formulations significantly increased the dissolution rate compared to pure Irbesartan and other carriers. Thus, using b-cyclodextrin in solid dispersions effectively enhances Irbesartan's solubility and therapeutic potential in treating hypertension. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability. Bestandsnummer des Verkäufers 9786208119713
Anzahl: 1 verfügbar