NEW METHOD DEVELOPMENT AND VALIDATION OF BEMPEDOIC ACID - Softcover

Karanam, Sridevi Ranjitha; Yarguntla, Srinivasa Rao; Kollabatthula, Vara Prasada Rao

Softcover

ISBN 10: 6208223563 ISBN 13: 9786208223564

Verlag: LAP LAMBERT Academic Publishing, 2024

Inhaltsangabe

A Visible Spectrophotometric method has been developed and validated for the quantitative measurement of Bempedoic acid in bulk and tablet dosage forms. The process is based on the production of a colored complex in the presence of Ferric chloride between Bempedoic acid and MBTH (3-methyl-2-benzothiazolinone Hydrazone). At 663 nm, the colored complex was spectrophotometrically measured. The correlation coefficient (r2) of 0.999 revealed that the approach is linear in the concentration range of 10-60 µg/mL. It was discovered that the limits of detection (LOD) and quantitation (LOQ) were 2.169 µg/mL and 6.572 µg/mL, respectively. For both intra-day and inter-day precision studies, the approach was proven to be precise with a percent relative standard deviation (%RSD) less than 2.0%. Recovery experiments were used to assess the method's accuracy, and it was discovered that the average percentage of recovery fell between 98.0 and 102.0%. The results of the suggested approach were compared to those of the reference method for the accurate determination of Bempedoic acid in tablet dosage forms.

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Über die Autorin bzw. den Autor

Dr. Sridevi Ranjitha Karanam is an Associate Professor in Pharmaceutical Analysis at Vignan Institute of Pharmaceutical Technology with 13 years of experience. She has authored 10 research papers and 3 review articles in national & international journals. Her expertise lies in method development and validation using advanced analytical techniques.

Details zur Ausgabe

• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsdatum: 2024
• Sprache: Englisch
• ISBN 10: 6208223563
• ISBN 13: 9786208223564
• Einband: Taschenbuch
• Anzahl der Seiten: 76
• Kontakt zum Hersteller: Edicoes Nosso Conhecimento; customerservice@vdm-vsg.de; ; SIA; Riga; 1039; Litauen