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SOLID DISPERSIONS – AN APPROACH TO ENHANCE THE DISSOLUTION RATE: DE - Softcover

Nagam, Santhi Priya; Pusuluri, Siva Krishna; Thalla, Sreenu

 
9786208424442: SOLID DISPERSIONS – AN APPROACH TO ENHANCE THE DISSOLUTION RATE: DE
Softcover
ISBN 10: 6208424445 ISBN 13: 9786208424442
Verlag: LAP LAMBERT Academic Publishing, 2025

Inhaltsangabe

Oxcarbazepine, 10, 11-dihydro- 10-oxo- 5H-dibenz(b,f)azepine- 5-carboxamide, is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy. It is also used to treat anxiety and mood disorders, and benign motor tics. Oxcarbazepine is marketed as Trileptal by Novartis and available in some countries as a generic drug. It is a prodrug which is activated to eslicarbazepine in the liver. It is a white or yellowish-white, crystalline powder; almost odourless, with a molecular weight of 252.268 g/mol. Oxcarbazepine is slightly soluble in acetone, chloroform, dichloromethane, and methanol. It is practically insoluble in ethanol, ether, and water. The drug exhibits low bioavailability related to its poor water solubility. Oxcarbazepine is a class II compound, i.e., water-insoluble, lipophilic, and highly permeable according to Biopharmaceutical Classification System. The purpose of this study was to prepare and characterize solid dispersions of the poor water soluble anticonvulsant with water soluble carrier such as primogel to improve its dissolution properties. The solid dispersions were prepared by co-grinding and solvent evaporation method.

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Über die Autorin bzw. den Autor

Mrs Nagam Santhi Priya, Associate Professor, Department of Pharmaceutics, Vignan Pharmacy College (Autonomous), Vadlamudi, Guntur, Andhra Pradesh. Her area of interest in novel drug delivery system, formulations, different dosage regimens.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2025
Sprache
Englisch
ISBN 10 
6208424445
ISBN 13 
9786208424442
Einband
Taschenbuch
Anzahl der Seiten
72
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
Fastbook Publishing
customerservice@vdm-vsg.de

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Riga
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