Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer: YAP in Oral Precancer and Oral Squamous Cell Carcinoma - Softcover

Nandhakumar, Indumathi; Thayalan, Dineshkumar

 
9786209363528: Yes Associated Protein (YAP) as a Prognostic Predictor in Oral Cancer: YAP in Oral Precancer and Oral Squamous Cell Carcinoma
Softcover
ISBN 10: 6209363520 ISBN 13: 9786209363528
Verlag: LAP LAMBERT Academic Publishing, 2025

Inhaltsangabe

This study explores the expression of Yes-associated protein (YAP), a key effector of the Hippo pathway, across the spectrum of oral carcinogenesis. Using immunohistochemistry on ethically sourced samples of normal oral mucosa, leukoplakia, and oral squamous cell carcinoma (OSCC), we observed a clear, progressive rise in YAP staining from healthy tissue to dysplasia and finally to OSCC. Dysplastic lesions showed stepwise increases in YAP intensity correlating with severity, while OSCC displayed the highest expression. Both nuclear and cytoplasmic staining were evident, with nuclear positivity (>10%) highlighting YAP’s active transcriptional role in promoting cell growth and malignant transformation. These findings suggest that YAP is a significant biomarker and potential driver of oral cancer progression.

Die Inhaltsangabe kann sich auf eine andere Ausgabe dieses Titels beziehen.

Über die Autorin bzw. den Autor

Dr. Indumathi Nandhakumar completed her MDS in Oral Pathology in November 2025. She currently serves as a Dental Medical Officer in a Government Hospital in Tamil Nadu. Passionate about diagnostic pathology and oral cancer research, she continues to combine clinical service with academic growth.

„Über diesen Titel“ kann sich auf eine andere Ausgabe dieses Titels beziehen.

Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2025
Sprache
Englisch
ISBN 10 
6209363520
ISBN 13 
9786209363528
Einband
Taschenbuch
Anzahl der Seiten
84
Kontakt zum Hersteller
preigu GmbH & Co. KG
mail@preigu.de

Lengericher Landstr. 19
Osnabrück
Niedersachsen
49078
Deutschland