Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy that is highly metastatic and typically diagnosed at advanced stages, resulting in poor prognosis. It accounts for 13-15% of all lung cancers and is strongly associated with smoking. The disease's rapid progression, tendency to develop resistance to chemotherapy, and frequent metastasis to the brain, liver, and bones present significant challenges for treatment. Initial therapy with chemotherapy, primarily platinum-based regimens, often yields good responses in limited-stage disease, but relapse occurs rapidly in most patients, with extensive-stage disease showing minimal long-term survival benefits. Recent advances in immunotherapy, particularly immune checkpoint inhibitors, have shown promise in improving outcomes, especially when combined with chemotherapy. Additionally, targeted therapies directed at specific molecular alterations such as MYC amplification and BCL2 overexpression are currently under investigation. Liquid biopsy technologies and molecular profiling are revolutionizing early detection and personalized treatment, offering hope for better treatment strategies.
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Dr. Wala BEN KRIDIS est professeur associé à la faculté de médecine de Sfax (Tunisie).Elle est titulaire d'un diplôme de médecine en oncologie (MD).Elle est titulaire d'un doctorat en sciences biologiques.Maîtrise en recherche clinique en sciences médicales.Réviseur pour Lancet Oncology.Rédactrice pour PLOS One.
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Taschenbuch. Zustand: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy that is highly metastatic and typically diagnosed at advanced stages, resulting in poor prognosis. It accounts for 13-15% of all lung cancers and is strongly associated with smoking. The disease's rapid progression, tendency to develop resistance to chemotherapy, and frequent metastasis to the brain, liver, and bones present significant challenges for treatment. Initial therapy with chemotherapy, primarily platinum-based regimens, often yields good responses in limited-stage disease, but relapse occurs rapidly in most patients, with extensive-stage disease showing minimal long-term survival benefits. Recent advances in immunotherapy, particularly immune checkpoint inhibitors, have shown promise in improving outcomes, especially when combined with chemotherapy. Additionally, targeted therapies directed at specific molecular alterations such as MYC amplification and BCL2 overexpression are currently under investigation. Liquid biopsy technologies and molecular profiling are revolutionizing early detection and personalized treatment, offering hope for better treatment strategies. 52 pp. Englisch. Bestandsnummer des Verkäufers 9786209440328
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Taschenbuch. Zustand: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy that is highly metastatic and typically diagnosed at advanced stages, resulting in poor prognosis. It accounts for 13-15% of all lung cancers and is strongly associated with smoking. The disease's rapid progression, tendency to develop resistance to chemotherapy, and frequent metastasis to the brain, liver, and bones present significant challenges for treatment. Initial therapy with chemotherapy, primarily platinum-based regimens, often yields good responses in limited-stage disease, but relapse occurs rapidly in most patients, with extensive-stage disease showing minimal long-term survival benefits. Recent advances in immunotherapy, particularly immune checkpoint inhibitors, have shown promise in improving outcomes, especially when combined with chemotherapy. Additionally, targeted therapies directed at specific molecular alterations such as MYC amplification and BCL2 overexpression are currently under investigation. Liquid biopsy technologies and molecular profiling are revolutionizing early detection and personalized treatment, offering hope for better treatment strategies. Bestandsnummer des Verkäufers 9786209440328
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Paperback. Zustand: new. Paperback. Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy that is highly metastatic and typically diagnosed at advanced stages, resulting in poor prognosis. It accounts for 13-15% of all lung cancers and is strongly associated with smoking. The disease's rapid progression, tendency to develop resistance to chemotherapy, and frequent metastasis to the brain, liver, and bones present significant challenges for treatment. Initial therapy with chemotherapy, primarily platinum-based regimens, often yields good responses in limited-stage disease, but relapse occurs rapidly in most patients, with extensive-stage disease showing minimal long-term survival benefits. Recent advances in immunotherapy, particularly immune checkpoint inhibitors, have shown promise in improving outcomes, especially when combined with chemotherapy. Additionally, targeted therapies directed at specific molecular alterations such as MYC amplification and BCL2 overexpression are currently under investigation. Liquid biopsy technologies and molecular profiling are revolutionizing early detection and personalized treatment, offering hope for better treatment strategies. This item is printed on demand. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability. Bestandsnummer des Verkäufers 9786209440328
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Taschenbuch. Zustand: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Small cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy that is highly metastatic and typically diagnosed at advanced stages, resulting in poor prognosis. It accounts for 13-15% of all lung cancers and is strongly associated with smoking. The disease's rapid progression, tendency to develop resistance to chemotherapy, and frequent metastasis to the brain, liver, and bones present significant challenges for treatment. Initial therapy with chemotherapy, primarily platinum-based regimens, often yields good responses in limited-stage disease, but relapse occurs rapidly in most patients, with extensive-stage disease showing minimal long-term survival benefits. Recent advances in immunotherapy, particularly immune checkpoint inhibitors, have shown promise in improving outcomes, especially when combined with chemotherapy. Additionally, targeted therapies directed at specific molecular alterations such as MYC amplification and BCL2 overexpression are currently under investigation. Liquid biopsy technologies and molecular profiling are revolutionizing early detection and personalized treatment, offering hope for better treatment strategies.VDM Verlag, Dudweiler Landstraße 99, 66123 Saarbrücken 52 pp. Englisch. Bestandsnummer des Verkäufers 9786209440328
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