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Development of Controlled-Release Three-Layered Diclofenac Tablet: Second Edition - Softcover

Arafat, Mohammad; Sultana, Farhana; Manirujjaman

 
9786630117257: Development of Controlled-Release Three-Layered Diclofenac Tablet: Second Edition
Softcover
ISBN 10: 6630117255 ISBN 13: 9786630117257
Verlag: LAP LAMBERT Academic Publishing, 2026

Inhaltsangabe

This book explores the development and evaluation of a controlled-release three-layered matrix tablet of diclofenac sodium, designed to achieve more consistent drug delivery than conventional dosage forms. The multilayer system combines a drug-containing core with two outer layers that differ in their swelling, gelling, and erosion properties, enabling modulation of the drug release rate and improving release kinetics. Diclofenac sodium, a widely used nonsteroidal anti-inflammatory drug (NSAID), serves as the model drug to investigate the influence of polymer composition and layer configuration on release behavior. Various formulations were prepared and compared through in vitro dissolution studies, with release profiles analyzed using zero-order kinetics. Although perfectly linear zero-order release was not achieved, statistically significant differences among the formulations demonstrate the impact of polymer matrices and tablet design on controlled drug delivery. The book provides valuable insights for students, researchers, and pharmaceutical scientists interested in modified-release dosage forms and formulation development.

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Über die Autorin bzw. den Autor

Mohammad Arafat is a Swedish Institute Scholar pursuing a Master's in Biomedicine and Methods in Medical Diagnostics (Experimental Medicine). He holds an M.S. in Pharmaceutical Technology and previously worked at Incepta Pharmaceuticals Ltd. Farhana Sultana and Manirujjaman hold B.Pharm. and M.Pharm. degrees and are active researchers.

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Verlag
LAP LAMBERT Academic Publishing
Erscheinungsdatum
2026
Sprache
Englisch
ISBN 10 
6630117255
ISBN 13 
9786630117257
Einband
Taschenbuch
Anzahl der Seiten
76
Kontakt zum Hersteller
Nicht verfügbar
Verantwortliche Person
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