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The Use of Short-And-Medium-Term Tests for Carcinogens and Data on Genetic Effects in Carcinogenic Hazard Evaluations (Iarc Scientific Publications, 146) - Softcover
Inhaltsangabe
Lifetime assays for carcinogenicity in experimental animals, together with data on genetic and related effects on a variety of organisms, have long been the foundation for predictions of carcinogenic hazard to human beings. Recent scientific advances have provided new assays and novel test systems that are beginning to supplement, and in the future may even replace, the well-established tests that have been widely used for the last four decades.
This publication reviews the evidence that justifies the use of lesions that precede histologically defined malignancy as endpoints to predict carcinogenicity. It evaluates the utility of non-mammalian species and of genetically engineered rodents as subjects for carcinogenicity tests and mutations in cancer-related genes in human and experimental animal tumours as 'footprints' of environmental carcinogens. It evaluates the use of established and novel assays for genetic toxicity in the prediction of carcinogenicity. Finally it formulates recommendations on the use of such data in the process of evaluation of carcinogenic hazards by theIARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
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Results of Short and Medium-Term Tests for Carcinogens and Data on Genetic and Related Effects in Carcinogenic Hazard Evaluations: No.146 . Research on Cancer Scientific Publications)
Verlag:
International Agency for Research on Cancer, France, 1999
ISBN 10: 928322146X
ISBN 13: 9789283221463
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Soft cover
Anbieter: Terry Blowfield, Norwich, NORFO, Vereinigtes Königreich
Verkäuferbewertung 5 von 5 Sternen
Soft cover. Zustand: Good. Published by International Agency for Research on Cancer of France in 1999. Soft cover, so no Dust Jacket. Book condition: Good. Both green cover and inside pages are in good order, apart from one page inside is loose from the binding. Additionally the previous owner of the book has written their name in red marker on the 1st inside pages. See photograph. 240mm x 170mm x 34mm. 536 pages. Please note that this book weighs over 1kg and will incur additional postage costs if purchased from abroad or if purchased in the UK for 1st class delivery. Bestandsnummer des Verkäufers 007509
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