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New Developments in the Pathogenesis of Rheumatoid Arthritis - Softcover

 
9789535129691: New Developments in the Pathogenesis of Rheumatoid Arthritis
Softcover
ISBN 10: 9535129694 ISBN 13: 9789535129691
Verlag: InTechOpen, 2017

Inhaltsangabe

The pathogenesis of rheumatoid arthritis (Ra) is incompletely understood. Hla class Ii alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (Acpas), along with the effectiveness of biological treatments targeting cytokines, such as Tnf-?, Il-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. Acpas, induced by cigarette smoking and periodontitis in individuals with Hla-Drb1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in Ra. MicroRnas, part of epigenetic mechanisms, which also include Dna methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

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Verlag
InTechOpen
Erscheinungsdatum
2017
Sprache
Englisch
ISBN 10 
9535129694
ISBN 13 
9789535129691
Einband
Taschenbuch
Anzahl der Seiten
162
Herausgeber
Sakkas Lazaros I.
Kontakt zum Hersteller
preigu GmbH & Co. KG
mail@preigu.de

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Osnabrück
Niedersachsen
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Deutschland