Part I: Prologue.- 1. A prologue to moyamoya disease and RNF213.- 2. Concept of moyamoya Disease.-
Part II: Genetic Epidemiology.- 3. Molecular Epidemiology in East Asian Countries and in the World.-
Part III: Biochemistry, Function and Molecular Pathology.-
4. Molecular Biology of Mysterin/RNF213.- 5. Physiological Role of Mysterin/RNF213 in Zebrafish.- 6. Pathological Investigation on RNF213: Animal Models Knockout and Transgenic Mice in Diabetes and Signal Transduction.- 7. Pathological Investigation on RNF213: Animal Models of Rnf213-knockout and Knock-in Mice.- 8. RNF213 and Circulating Factors in Patients with Moyamoya Disease .- 9. Genetics of Moyamoya beyond RNF213. Monogenic Moyamoya Syndromes.-
Part IV: Clinical Management
10. Natural History and Long-term Clinical Outcome after Conservative and Surgical Management.- 11. Significance of RNF213 in Clinical Management in Japan.- 12. Significance of RNF213 in Clinical Management in China.- 13. The Different Forms of Moyamoya Disease and Their Clinical Management.- 14. Vascular Diseases Attributable to RNF213 Other than Moyamoya Disease.-
Part V: Epilogue.- Future Clinical Perspectives on RNF213 in Moyamoya Disease.
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