Systematic Exploration of Indolizine-Based Small Fluorescent Molecules: Synthesis, Analysis and Application (Springer Theses) - Softcover

Buch 498 von 797: Springer Theses

Lee, Youngjun

 
9789811346606: Systematic Exploration of Indolizine-Based Small Fluorescent Molecules: Synthesis, Analysis and Application (Springer Theses)
Softcover
ISBN 10: 9811346607 ISBN 13: 9789811346606
Verlag: Springer, 2018

Inhaltsangabe

This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter.

Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. Understanding of the structure-photophysical property relationship of a given fluorophore often paves the road to the development of valuable molecular probes to visualize and transcribe biological networks. In this thesis, respective chapters deal with molecular design, organic synthesis, structure-property analysis, and quantum-mechanical interpretation of unexplored family of indolizine-based molecules. This systematic exploration has led to rational development of a new microalgae lipid droplet probe, colorful bioorthogonal fluorogenic probes, and a bright mitochondrial probe, working underlive cell conditions.

Harnessing the optical properties of a given fluorophore has been an important topic for a couple of decades, both in industry and in academia. This thesis provides useful insights for the improvement and development of unique small fluorescent materials, or optical materials.

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Über die Autorin bzw. den Autor

Dr. Youngjun Lee is a member of CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Korea. He earned Ph.D. degree in organic chemistry at SNU in February 2018.

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This thesis describes an in-depth study of an indolizine-based fluorophore, from understanding of its structure-photophysical property relationship to its application as a useful biological reporter.

Organic fluorophores have been extensively used in the field of molecular biology owing to their excellent photophysical property, suitable cell permeability, and synthetic flexibility. Understanding of the structure-photophysical property relationship of a given fluorophore often paves the road to the development of valuable molecular probes to visualize and transcribe biological networks. In this thesis, respective chapters deal with molecular design, organic synthesis, structure-property analysis, and quantum-mechanical interpretation of unexplored family of indolizine-based molecules. This systematic exploration has led to rational development of a new microalgae lipid droplet probe, colorful bioorthogonal fluorogenic probes, and a bright mitochondrial probe, working under livecell conditions.

Harnessing the optical properties of a given fluorophore has been an important topic for a couple of decades, both in industry and in academia. This thesis provides useful insights for the improvement and development of unique small fluorescent materials, or optical materials.

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Verlag
Springer
Erscheinungsdatum
2018
Sprache
Englisch
ISBN 10 
9811346607
ISBN 13 
9789811346606
Einband
Taschenbuch
Anzahl der Seiten
216
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9789811316449: Systematic Exploration of Indolizine-Based Small Fluorescent Molecules: Synthesis, Analysis and Application (Springer Theses)

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ISBN 10:  9811316449 ISBN 13:  9789811316449
Verlag: Springer, 2018
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