Bleeding means loss of blood from the body. Blood loss, medically known as ‘‘haemorrhage’’ could be a life-threatening condition. Depending on the severity or volume of blood loss, it could lead to anaemia and ultimately to death. A bleeding disorder is any disorder that causes loss of blood from the body. Bleeding may result from acquired causes such as trauma, road traffic accidents and surgical interventions, which are modifiable. However, genetic bleeding disorders are more worrisome to the physician because of their public health implications. Haemophilia is a common genetic bleeding disorder which is transmissible to generations. Over 200,000 people globally are carrying this bleeding gene, which is responsible for excessive blood loss, especially during early childhood, if undetected. The fascinating thing about haemophilia is its male gender disparity. It is usually transmitted from female carriers to their sons. Haemophilia carries terrible medical and psychosocial consequences. The sufferers usually present with deep muscle bleeding, bleeding into the joints (otherwise known as hemarthrosis), joint deformities, and bleeding through the orifices. In severe conditions, it leads to absenteeism, out-of-school children, poor performance, anxiety, depression and a lack of attainment of developmental goals, especially when it manifests in early childhood. There are two major subtypes of haemophilia, namely, haemophilia A and B. Haemophilia is a unique type of bleeding disorder because the gene is transmitted from mother to son, and so males gender tend to suffer from haemophilia more than females. This book will explore haemophilia, its classifications, diagnosis, and treatment. It will delve into the public health challenges of the disease burden and both the traditional and modern strategic approaches of its prevention and treatment. The impact of the various drugs for preventing blood loss, such as antifibrinolytics (i.e., tranexamic acid), combined oral contraceptive pills, factor replacement and gene therapies, will be robustly discussed in clear terms without ambiguity. This book is a "must-read" for those who want to take care of their health and for those living with genetic bleeding disorders. The roles of the family and community in the palliative care of inherited bleeding disorders were explored in this book. Other interesting topical issues that will enable the reader to navigate through the crucibles of this genetic bleeding disorder are how lifestyle modifications, genetic counselling, gene therapies, reproductive education, advocacies and modern advances in technology are improving the landscape of management of Haemophilia in modern medicine. Relax and enjoy every moment you spend reading this medical literature presented as case scenarios.
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