ATORVASTATIN SELF-EMULSIFIED TABLETS FORMULATION AND EVALUATION: SELF-EMULSIFIED DRUG DELIVERY SYSTEM

Biswal, Prasanta Kumar,SAHU, PRAFULLA KUMAR

ISBN 10: 6205528088 / ISBN 13: 9786205528082

Verlag: LAP LAMBERT Academic Publishing, 2022

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Inhaltsangabe:

Due to poor drug solubility and absorption, many drug candidates fall short of expectations. Self-emulsifying drug delivery methods increase the solubility and bioavailability of poorly soluble medications. When SEDDS are added to an aqueous phase and gently mixed, fine oil-in-water emulsions form. SEDDS come in soft or hard gelatin capsules for oral administration and form fine, stable oil-in-water emulsions. SEDDS are primarily manufactured as liquid formulations, which have poor stability and mobility, low drug loading, a limited number of dosage form options, irreversible drug/excipient precipitation, and a high proportion (30–60%) of surfactants that might irritate the gastrointestinal system. Solid-SEDDS has been studied to avoid the problems of liquid SEDDS. The adsorption of liquid self-micro-emulsified formulations on solid carriers is one of the best ways to create free-flowing powders for compression into tablet dosage form (SMET).

Über die Autorin bzw. den Autor: A Dra. Prasanta Kumar Biswal está actualmente a trabalhar como Professora e Chefe do Departamento de Farmácia, Gayatri College of Pharmacy, Sambalpur, Odisha, Índia.O Dr. Prafulla Kumar Sahu, Ph.D. está a trabalhar como Professor Principal cum na Faculdade de Farmácia, Universidade de Tecnologia e Gestão do Centurião, Campus de Bolangir.

Bibliografische Details

Titel: ATORVASTATIN SELF-EMULSIFIED TABLETS ...
Verlag: LAP LAMBERT Academic Publishing
Erscheinungsdatum: 2022
Einband: paperback
Zustand: Very Good