Alternative methods for obtaining of cherylline derivatives

Manolov, Stanimir/ Ivanov, Iliyan

ISBN 10: 620207857X / ISBN 13: 9786202078573

Verlag: LAP LAMBERT Academic Publishing, 2017

Beschreibung

52 pages. 8.66x5.91x0.12 inches. In Stock.

Bestandsnummer des Verkäufers zk620207857X

Bibliografische Details

• Titel: Alternative methods for obtaining of cherylline derivatives
• Verlag: LAP LAMBERT Academic Publishing
• Erscheinungsjahr: 2017
• Sprache: Englisch
• ISBN-10: 620207857X
• ISBN-13: 9786202078573
• Einband: Paperback
• Zustand: Brand New
• Gewicht: 0,13 Kilogramm

Über diesen Titel

Inhaltsangabe

In this book are presented the results from research on alternative approaches towards the synthesis of 4- aryl-l,2,3,4-tetrhydroisoquinolines as synthetic analogues of the alkaloid cherylline. Optimal conditions for the synthesis of the required 2,2-disubstituted ethylamine precursors are found. The Schotten- Baumann method for amide synthesis is then successfully applied and the synthesized amides are used in an intramolecular α-amidoalkylation reaction to obtain 4-substituted 1,2,3,4-tetrahydroisoquinolines. An eco-friendly procedure utilizing PPA/SiO2 catalyst for the intramolecular α -amidoalkylation is developed. Microwave-assisted variant of this eco-friendly procedure is also successfully developed. By the Bischler-Napieralski method are synthesized five new 1,4- disubstituted-l,2,3,4-tetrahydroisoquinolines. These are potential inhibitors of DHODH. It is found that the reduction of 1,4-disubstituted 3,4-dihydroisoquinolines leads to formation of diastereoisomers. The diastereoisomers are successfully separated by preparative column chromatography and 2:1 (cis:trans) ratio is determined. This ratio is not affected by the temperature at which the reaction is carried out.