Amorphous Food and Pharmaceutical Systems
Sprache: Englisch
Verlag: RSC Publishing, 2002
- Hardcover
- Neu
Anbieter: PBShop.store UK, Fairford, GLOS, Vereinigtes KönigreichPBShop.store UK
Verkäufer:in bei AbeBooks seit 11. Juni 1999
Zustand: Neu
EUR 133,15
Anzahl: 15 verfügbar
In den WarenkorbArtikelbeschreibung des Verkäufers
New Book. Shipped from UK. Established seller since 2000.
Bestandsnummer des Verkäufers CX-9780854048663
- Titel
- Amorphous Food and Pharmaceutical Systems
- Verlag
- RSC Publishing
- Erscheinungsjahr
- 2002
- Zustand
- New
- Einband
- HRD
- Sprache
- Englisch
- ISBN-10
- 0854048669
- ISBN-13
- 9780854048663
- Artikelgewicht
- 801 Gramm
During the past decade, the importance of amorphous water-soluble substances has been increasingly recognised within the food and pharmaceutical industries. In response, Amorphous Food and Pharmaceutical Systems brings together current leading experts to contribute to this unique cross-disciplinary account of the subject. Coverage includes: water-compatible amorphous solids (physical, chemical behaviour), low water content systems (water as plasticizer); applications in food and pharmaceutical sciences and industries (processing and stability) along with state-of-the-art technology in food and pharmaceutical systems. This timely publication will be welcomed by academic and industrial researchers and professionals in the pharmaceuticals, food, materials and polymer sciences.
„Inhaltsangabe“ gehört möglicherweise zu einer anderen Auflage dieses Titels.
Auszug. © Genehmigter Nachdruck. Alle Rechte vorbehalten.
Amorphous Food and Pharmaceutical Systems
By Harry LevineThe Royal Society of Chemistry
All rights reserved.
Contents
Introduction – Progress in Amorphous Food and Pharmaceutical Systems H. Levine, 1,
Structure and its Significance in the Application Technology of Amorphous Materials,
The Concept of 'Structure' in Amorphous Solids from the Perspective of the Pharmaceutical Sciences E. Shalaev and G. Zografi, 11,
Analytical Model for the Prediction of Glass Transition Temperature of Food Systems V. Truong, B.R. Bhandari, T. Howes and B. Adhikari, 31,
Microstructural Domains in Foods: Effect of Constituents on the Dynamics of Water in Dough, as Studied by Magnetic Resonance Spectroscopy Y. Kou, E. W. Ross and I.A. Taub, 48,
Supplemented State Diagram for Sucrose from Dynamic Mechanical Thermal Analysis I. Braga da Cruz, W.M. MacInnes, J.C. Oliveira and F.X. Malcata, 59,
Glassy State Dynamics and its Significance for Stabilization of Labile Bioproducts,
Glassy State Dynamics, its Significance for Biostabilisation and the Role of Carbohydrates R. Parker, Y.M. Gunning, B. Lalloué, T.R. Noel and S.G. Ring, 73,
Influence of Physical Ageing on Physical Properties of Starchy Materials D. Lourdin, P. Colonna, G. Brownsey and S. Ring, 88,
Uptake and Transport of Gas in Microstructured Amorphous Matrices A. Schoonman, J.B. Ubbink, W.M. MacInnes and H.J. Watzke, 98,
Theories of Unstable Aqueous Systems: How Can They Help the Technologist?,
Recent Developments in the Theory of Amorphous Aqueous Systems P.G. Debenedetti and J.R. Errington, 115,
Studies on Raffinose Hydrates K. Kajiwara, A. Motegi, M. Sugie, F. Franks, S. Munekawa, T. Igarashi and A. Kishi, 121,
Comparison between WLF and VTF Expressions and Related Physical Meaning A. Schiraldi, 131,
Progress in Food Processing and Storage,
Progress in Food Processing and Storage, Based on Amorphous Product Technology L. Slade and H. Levine, 139,
The Effect of Microstructure on the Complex Glass Transition Occurring in Frozen Sucrose Model Systems and Foods H.D. Goff, K. Montoya and M.E. Sahagian, 145,
Relationship between the Glass Transition, Molecular Structure and Functional Stability of Hydrolyzed Soy Proteins V. Zylberman and A.M.R. Pilosof, 158,
A Study of Vitrification of Australian Honeys at Different Moisture Contents P.A. Sopade, B. Bhandari, B. D'Arcy, P. Halley and N. Caffin, 169,
Rational Pharmaceutical Formulation of Amorphous Products,
Rational Formulation Design – Can the Regulators be Educated? T. Auffret, 187,
Solid–Liquid State Diagrams in Pharmaceutical Lyophilisation: Crystallization of Solutes E. Shalaev and F. Franks, 200,
Miscibility of Components in Frozen Solutions and Amorphous Freeze-dried Protein Formulations K.-I. Izutsu and S. Kojima, 216,
Investigations into the Amorphous and Crystalline Forms of a Development Compound D. O'Sullivan, G. Steele and T.K. Austin, 220,
Thermophysical Properties of Amorphous Dehydrated and Frozen Sugar Systems, as Affected by Salts M.F. Mazzobre, M.P. Longinotti, H.R. Corti and M.P. Buera, 231,
Glass-forming Ability of Polyphosphate Compounds and Their Stability K. Kawai, T. Suzuki, T. Hagiwara and R. Takai, 244,
Chemistry in Solid Amorphous Matrices,
Chemistry in Solid Amorphous Matrices: Implication for Biostabilization M.J. Pikal, 257,
Residual Water, its Measurement, and its Effects on Product Stability,
Residual Water in Amorphous Solids: Measurement and Effects on Stability D. Lechuga-Ballesteros, D.P. Miller and J. Zhang, 275,
A Decrease in Water Adsorption Ability of Amorphous Starch Subjected to Prolonged Ball-milling is Accompanied by Enthalpy Relaxation T. Suzuki, Y.J. Kim, C. Pradistsuwana and R. Takai, 317,
Novel Experimental Approaches to Studies of Amorphous Aqueous Systems,
Use, Misuse and Abuse of Experimental Approaches to Studies of Amorphous Aqueous Systems D.S. Reid, 325,
Glass Transition and Ice Crystallisation of Water in Polymer Gels, Studied by Oscillation DSC, XRD–DSC Simultaneous Measurements, and Raman Spectroscopy N. Murase, M. Ruike, S. Yoshioka, C. Katagiri and H. Takahashi, 339,
Subject Index, 347,
CHAPTER 1
The Concept of 'Structure' in Amorphous Solids from the Perspective of the Pharmaceutical Sciences
Evgenyi Shalaev and George Zografi
1 Introduction
Partially or completely amorphous pharmaceutical materials are often created during the manufacture of dosage forms, when an initially highly crystalline bulk drug is processed by standard methods, such as milling, compaction, wet granulation, freeze-drying and spray-drying. The importance of amorphous materials in pharmaceutical research and development has been highlighted in a number of reviews. Formation of a disordered solid may be intentional, when higher solubility and bioavailability are desired, or it may be accidental, during the processing of crystalline materials. In both cases, the physical and chemical stability of such a disordered solid drug must be considered to have possibly been compromised. Because of the very strict regulatory requirements for maintaining the stability of pharmaceuticals, an understanding of amorphous/crystal relationships is an essential part of the drug development process.
In the pharmaceutically related literature on amorphous solids, the main focus has been on studies of the relationships between molecular mobility and chemical and physical stability. In particular, many efforts have been devoted to identifying a 'critical' temperature, below which an amorphous material will be completely stable on practical time scales. Candidates for such a critical stability temperature include the glass transition temperature (Tg) a 'chemical reaction glass transition temperature' and the Kauzmann temperature (TK or T0) (see refs. 4–7 for examples). It has been recognized, however, that although molecular mobility is important, it is not the only factor that determines the stability of amorphous solids. For example, it has been suggested recently that effects (e.g. polarity) of the medium can be important in controlling the chemical stability of amorphous solids. In particular, the role of 'solid-state pH' in amorphous systems is attracting increasing attention in the pharmaceutical literature.
Another critical factor that is expected to have a significant impact on the stability of amorphous solids is the structural nature of molecules in the solid state. Indeed, there are well-established relationships between crystal structure and chemical reactivity in crystalline solids. However, studies on amorphous structure/stability relationships are still under-represented in the pharmaceutical literature. In the present paper, we review different aspects of the structural features of amorphous solids, in relation to their chemical and physical stability. The paper includes five following sections. In the first, we ask the following question, 'is there more than one amorphous state of the same material?' In particular, the issue of 'polyamorphism' is considered. Both true polyamorphism (i.e. involving a phase transition between two amorphous phases) and relaxation 'polyamorphism', where there is a continuous space of dynamic amorphous states, are discussed. The second section is devoted to the microscopic heterogeneity of amorphous materials, and in...
„Über diesen Titel“ gehört möglicherweise zu einer anderen Auflage dieses Titels.
PBShop.store UK
Fairford, GLOS, Vereinigtes Königreich
Verkäufer:in bei AbeBooks seit 11. Juni 1999
Versandkosten von Vereinigtes Königreich nach USA
| Artikel | 10 bis 20 Werktage | 10 bis 20 Werktage |
|---|---|---|
| Erster Artikel | EUR 6,99 | EUR 7,02 |
Zahlungsarten
Shopbeschreibung
**Please note our transit times are from the date of dispatch.** We first started out as “The Paperback Exchange,” a chain of physical bookstores where we would part exchange your beloved books for new stories to transport you to faraway places. However, as shopping started to evolve to online shops and marketplaces, we bid our stores goodbye to become “PBShop.” This transition has only allowed us to blossom as we now ship thousands of titles to book lovers across the globe. We pride ourselves in being a community of local book lovers which allows our passion and devotion to shine in everything we do. In 2020 we not only celebrated our 20th birthday but our 1st birthday as being completely employee owned after becoming an E.O.T in September 2019. We are proud to be different and embrace standing apart on a book mountain by working from a virtual inventory which allows us to provide thousands of books that may be difficult to get for your bookshelf or your studies. Working with a number of different suppliers allows us to explore other avenues such as puzzles, sheet music and even stationery so we really do have something for everyone. Life is about being versatile in all realms of existence. If this is your first purchase with us, or you are a returning customer, we would like to welcome you to the PBShop family, for there is no friend as loyal as a book. We are a company who put our customers at the centre of everything we do as we understand the importance of reading because once you learn to read, you will forever be free. There are a whole lot of things in this world of ours that we are yet to explore, which is why we will forever inspire curious minds.…
Spezialisierung
Hardbacks, PaperbacksUnternehmensdaten der Verkäuferin bzw. des Verkäufers
Pbshop.co.uk
Unit 22 Horcott Industrial Estate, Horcott Road
Fairford, Vereinigtes Königreich GL7 4BX
Verkaufsbedingungen
Returns Policy
We ask all customers to contact us for authorisation should they wish to return their order. Orders returned without authorisation may not be credited.
If you wish to return, please contact us within 14 days of receiving your order to obtain authorisation.
Returns requested beyond this time will not be authorised.
Our team will provide full instructions on how to return your order and once received our returns department will process your refund.
Please note the cost to return any unwanted order to us is borne by the buyer.
Should your order arrive damaged, not as advertised or faulty, we must be advised of this within 14 days of delivery. Please contact us so we can find the best solution for you.
Our Customer Care Team can be contacted by emailing alborders@paperbackshop.co.uk, or by calling our UK Office on +441285 712 917. We are available 9:00am till 5:30pm GMT Monday to Friday.
Widerrufsrecht
Wenn Sie Verbraucher sind, können Sie gemäß den folgenden Bestimmungen vom Vertrag zurücktreten. Verbraucher ist jede natürliche Person, die zu Zwecken handelt, die nicht ihrer kaufmännischen, gewerblichen, künstlerischen oder beruflichen Tätigkeit zugerechnet werden können.
Informationen zum Widerrufsrecht
Gesetzliches Widerrufsrecht
Sie haben das Recht, den Vertrag innerhalb von 14 Tagen ohne Angabe von Gründen zu widerrufen.
Die Widerrufsfrist beträgt 14 Tage ab dem Tag, an dem Sie oder ein von Ihnen benannter Dritter, der nicht der Transporteur ist, die letzte Ware oder den letzten Posten oder das letzte Exemplar in Besitz genommen hat.
Um das Widerrufsrecht auszuüben, füllen Sie auf unserer Website unter „Meine Einkäufe" in „Mein Nutzerkonto" eine eindeutige Erklärung elektronisch aus und senden Sie sie ab. Wir werden Ihnen unverzüglich eine Bestätigung über den Eingang eines solchen Widerrufs auf einem dauerhaften Datenträger (z. B. per E-Mail) übermitteln.
Um die Widerrufsfrist einzuhalten, reicht es aus, dass Sie Ihre Mitteilung über die Ausübung des Widerrufsrechts vor Ablauf der Widerrufsfrist absenden.
Auswirkungen des Widerrufs
Wenn Sie diesen Vertrag widerrufen, erstatten wir Ihnen alle Zahlungen, die wir von Ihnen erhalten haben, einschließlich der Lieferkosten (mit Ausnahme der zusätzlichen Kosten, die entstehen, wenn Sie eine andere Art der Lieferung als die von uns angebotene günstigste Standardlieferung gewählt haben).
Wir können einen Abzug von der Rückerstattung für den Wertverlust der gelieferten Waren vornehmen, wenn der Verlust auf eine unnötige Behandlung durch Sie zurückzuführen ist.
Wir werden die Rückerstattung unverzüglich und nicht später als 14 Tage nach dem Tag vornehmen, an dem wir über Ihre Entscheidung, diesen Vertrag zu widerrufen, informiert wurden.
Für die Rückerstattung verwenden wir dasselbe Zahlungsmittel, das Sie für die ursprüngliche Transaktion verwendet haben, es sei denn, Sie haben ausdrücklich etwas anderes vereinbart; in keinem Fall werden Ihnen aufgrund einer solchen Rückerstattung Gebühren berechnet.
Wir können die Rückzahlung verweigern, bis wir die Waren wieder zurückerhalten haben oder Sie den Nachweis erbracht haben, dass Sie die Waren zurückgesandt haben, je nachdem, was eher eintritt.
Sie müssen die Waren unverzüglich und in jedem Fall spätestens 14 Tage ab dem Tag, an dem Sie uns über den Widerruf dieses Vertrags unterrichten, an PBShop.store UK, Fairford, United Kingdom, +44 1285 712917, zurücksenden oder übergeben. Die Frist ist eingehalten, wenn Sie die Ware vor Ablauf der Frist von 14 Tagen zurücksenden. Sie müssen die direkten Kosten der Rücksendung der Waren tragen. Sie haften nur für einen etwaigen Wertverlust der Waren, der auf eine Behandlung zurückzuführen ist, die nicht zur Prüfung der Art, Eigenschaften und Funktionsweise der Waren erforderlich ist.
Ausnahmen vom Widerrufsrecht
Das Widerrufsrecht gilt nicht für:
- Die Lieferung von Zeitungen, Zeitschriften oder Magazinen mit Ausnahme von Abonnementverträgen; und
- Die Lieferung digitaler Inhalte, die nicht auf einem physischen Medium (z. B. auf einer CD oder DVD) geliefert werden, wenn Sie bei Ihrer Bestellung akzeptiert haben, dass wir mit der Lieferung beginnen können und dass Sie nach Beginn der Lieferung den Vertrag nicht mehr widerrufen können.
Versandbedingungen
Orders are shipped from our UK warehouse. Delivery thereafter is between 4 and 14 business days. Please contact us if you have any queries about our services or products.