Chorionic Gonadotropin

Sheldon J. Segal

ISBN 10: 1468410644 / ISBN 13: 9781468410648

Verlag: Springer US, Chapman And Hall/CRC Feb 2012, 2012

Beschreibung

This item is printed on demand - it takes 3-4 days longer - Neuware -This volume is devoted to the chemistry, immunology, molecular biology, and physiology of the human chorionic gonadotropin, heG. For this glycoprotein molecule the course from discovery to chemical deciphering covered about fifty years. It was in 1928 that Ascheim and Zondek reported that urine from pregnant women contains something that stimulates the ovaries of mice or rats. This provided the basis for the famous A-Z test for pregnancy and for the 'rabbit test' modification introduced by Friedman. As researchers sought to find more sensitive responses to heG, they used a wide variety of species including the South African aquatic toad, Xenopus Zaevis, the terrestrial toad of South America, Bufo arinarus, and the African weaver finch, EupZeetes afra. The weaver finch feather reaction was particularly noteworthy, for it disclosed a non-gonadal response to heG/LH. In retrospect, this may have been an important evolutionary clue to the realization that the designation of the hormone as a 'gonadotropin' may have been only partially descriptive of the molecule's physiological function--a concept that is gaining attention, as the papers in this 1980 volume divulge. 520 pp. Englisch.

Bestandsnummer des Verkäufers 9781468410648

Bibliografische Details

• Titel: Chorionic Gonadotropin
• Verlag: Springer US, Chapman And Hall/CRC Feb 2012
• Erscheinungsjahr: 2012
• Sprache: Englisch
• ISBN-10: 1468410644
• ISBN-13: 9781468410648
• Einband: Taschenbuch
• Zustand: Neu
• Abmessungen: 244B x 170 H x 28 T Millimeter Breite: 244 mm, Höhe: 170 mm, Tiefe: 28 mm
• Gewicht: 887 Gramm

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Inhaltsangabe

This volume is devoted to the chemistry, immunology, molecular biology, and physiology of the human chorionic gonadotropin, heG. For this glycoprotein molecule the course from discovery to chemical deciphering covered about fifty years. It was in 1928 that Ascheim and Zondek reported that urine from pregnant women contains something that stimulates the ovaries of mice or rats. This provided the basis for the famous A-Z test for pregnancy and for the "rabbit test" modification introduced by Friedman. As researchers sought to find more sensitive responses to heG, they used a wide variety of species including the South African aquatic toad, Xenopus Zaevis, the terrestrial toad of South America, Bufo arinarus, and the African weaver finch, EupZeetes afra. The weaver finch feather reaction was particularly noteworthy, for it disclosed a non-gonadal response to heG/LH. In retrospect, this may have been an important evolutionary clue to the realization that the designation of the hormone as a "gonadotropin" may have been only partially descriptive of the molecule's physiological function--a concept that is gaining attention, as the papers in this 1980 volume divulge.