THIS WORK OFFERS A GUIDED WALKTHROUGH OF ONE OF THE MOST PROMISING RESEARCH AREAS IN MODERN LIFE SCIENCES, ENABLING A DEEPER UNDERSTANDING OF INVOLVED CONCEPTS AND METHODOLOGIES VIA AN INTERDISCIPLINARY VIEW, FOCUSING ON BOTH WELL-ESTABLISHED APPROACHES AND CUTTING-EDGE RESEARCH. HIGHLIGHTING WHAT PATHWAY ANALYSIS CAN OFFER TO BOTH THE EXPERIMENTALIST AND THE MODELER, THE TEXT OPENS WITH AN INTRODUCTION TO A GENERAL METHODOLOGY THAT OUTLINES COMMON WORKFLOWS SHARED BY SEVERAL METHODS. THIS IS FOLLOWED BY A REVIEW OF PATHWAY AND SUB-PATHWAY BASED APPROACHES FOR SYSTEMS PHARMACOLOGY. THE WORK THEN PRESENTS AN OVERVIEW OF PATHWAY ANALYSIS METHODS DEVELOPED TO MODEL THE TEMPORAL ASPECTS OF DRUG- OR DISEASE-INDUCED PERTURBATIONS AND EXTRACT RELEVANT DYNAMIC THEMES. THE TEXT CONCLUDES BY DISCUSSING SEVERAL STATE-OF-THE-ART METHODS IN PATHWAY ANALYSIS, WHICH ADDRESS THE IMPORTANT PROBLEM OF IDENTIFYING DIFFERENTIALLY EXPRESSED PATHWAYS AND SUB-PATHWAYS.<P></P>

Rese�a del editor:

This work offers a guided walkthrough of one of the most promising research areas in modern life sciences, enabling a deeper understanding of involved concepts and methodologies via an interdisciplinary view, focusing on both well-established approaches and cutting-edge research. Highlighting what pathway analysis can offer to both the experimentalist and the modeler, the text opens with an introduction to a general methodology that outlines common workflows shared by several methods. This is followed by a review of pathway and sub-pathway based approaches for systems pharmacology. The work then presents an overview of pathway analysis methods developed to model the temporal aspects of drug- or disease-induced perturbations and extract relevant dynamic themes. The text concludes by discussing several state-of-the-art methods in pathway analysis, which address the important problem of identifying differentially expressed pathways and sub-pathways.

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