Computational Methods in Protein Evolution (Methods in Molecular Biology (1851))

ISBN 10: 149399378X / ISBN 13: 9781493993789

Verlag: Humana Press, 2019

Beschreibung

pp. 433.

Bestandsnummer des Verkäufers 26383619258

Bibliografische Details

• Titel: Computational Methods in Protein Evolution (Methods in Molecular Biology (1851))
• Verlag: Humana Press
• Erscheinungsjahr: 2019
• Sprache: Englisch
• ISBN-10: 149399378X
• ISBN-13: 9781493993789
• Einband: Softcover
• Zustand: New

Über diesen Titel

Inhaltsangabe

This volume presents a diverse collection of methodologies used to study various problems at the protein sequence and structure level. The chapters in this book look at issues ranging from broad concepts like protein space to specifics like antibody modeling. Topics include point mutations, gene duplication, de novo emergence of new genes, pairwise correlated mutations, ancestral protein reconstruction, homology modelling, protein stability and dynamics, and protein-protein interactions. The book also covers a wide range of computational approaches, including sequence and structure alignments, phylogenies, physics-based and mathematical approaches, machine learning, and more. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and prerequisites, step-by-step, readily reproducible computational protocols (using command line or graphical user interfaces, sometimes including computer code), and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and authoritative, Computational Methods in Protein Evolution is a valuable resource that offers useful workflows and techniques that will help both novice and expert researchers working with proteins computationally.