Contemporary Accounts in Drug Discovery and Development (Hardcover)

Xianhai Huang

ISBN 10: 1119627710 / ISBN 13: 9781119627715

Verlag: John Wiley & Sons Inc, New York, 2022

Beschreibung

Hardcover. CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENT A useful guide for medicinal chemists and pharmaceutical scientists Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners knowledge of chemistry and biology, but alsoand perhaps more importantlyon experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field. Contemporary Accounts in Drug Discovery and Development provides drug discovery scientists with the knowledge they need to quickly gain mastery of the drug discovery process. A thorough accounting is given for each drug covered within the book, as the authors provide pharmacology, drug metabolism, biology, drug development, and clinical studies for every case, with modern drug discovery principles and technologies incorporated throughout. Contemporary Accounts in Drug Discovery and Development readers will also find Case histories used as an engaging way of learning about the drug discovery/development processDetailed biological rational and background information, drug design principles, SAR development, ADMET considerations, and clinical studiesThe full history of individual marketed small molecule drugsCoverage of drug candidates that have passed Phase I clinical trials with different modalities, such as antibody drug conjugates (ADC), proteolysis-targeting chimera (PROTAC), and peptide drugsThe application of new technologies in drug discovery such as DNA-encoded libraries (DEL), positron emission tomography (PET), and physics-based computational modeling employing free energy perturbation (FEP) Contemporary Accounts in Drug Discovery and Development is a helpful tool for medicinal chemists, organic chemists, pharmacologists, and other scientists in drug research and process development. It may be considered essential reading for graduate courses in drug discovery, medicinal chemistry, drug synthesis, pharmaceutical science, and pharmacology. It is also a useful resource for pharmaceutical industry labs, as well as for libraries. Preceded by Case studies in modern drug discovery and development / edited by Xianhai Huang, Robert G. Aslanian. 2012. Shipping may be from our UK warehouse or from our Australian or US warehouses, depending on stock availability.

Bestandsnummer des Verkäufers 9781119627715

Bibliografische Details

• Titel: Contemporary Accounts in Drug Discovery and Development (Hardcover)
• Verlag: John Wiley & Sons Inc, New York
• Erscheinungsjahr: 2022
• Sprache: Englisch
• ISBN-10: 1119627710
• ISBN-13: 9781119627715
• Einband: Hardcover
• Zustand: new

Über diesen Titel

Inhaltsangabe

CONTEMPORARY ACCOUNTS IN DRUG DISCOVERY AND DEVELOPMENT

A useful guide for medicinal chemists and pharmaceutical scientists

Drug discovery is a lengthy and complex process that typically involves identifying an unmet medical need, determining a biological target, chemical library screening to identify a lead, chemical optimization, preclinical studies and clinical trials. This process often takes many years to complete, and relies on practitioners’ knowledge of chemistry and biology, but also―and perhaps more importantly―on experience. Improving the success rate in discovery and development through a thorough knowledge of drug discovery principles and advances in technology is critical for advancement in the field.

Contemporary Accounts in Drug Discovery and Development provides drug discovery scientists with the knowledge they need to quickly gain mastery of the drug discovery process. A thorough accounting is given for each drug covered within the book, as the authors provide pharmacology, drug metabolism, biology, drug development, and clinical studies for every case, with modern drug discovery principles and technologies incorporated throughout.

Contemporary Accounts in Drug Discovery and Development readers will also find

• Case histories used as an engaging way of learning about the drug discovery/development process
• Detailed biological rational and background information, drug design principles, SAR development, ADMET considerations, and clinical studies
• The full history of individual marketed small molecule drugs
• Coverage of drug candidates that have passed Phase I clinical trials with different modalities, such as antibody drug conjugates (ADC), proteolysis-targeting chimera (PROTAC), and peptide drugs
• The application of new technologies in drug discovery such as DNA-encoded libraries (DEL), positron emission tomography (PET), and physics-based computational modeling employing free energy perturbation (FEP)

Contemporary Accounts in Drug Discovery and Development is a helpful tool for medicinal chemists, organic chemists, pharmacologists, and other scientists in drug research and process development. It may be considered essential reading for graduate courses in drug discovery, medicinal chemistry, drug synthesis, pharmaceutical science, and pharmacology. It is also a useful resource for pharmaceutical industry labs, as well as for libraries.

Über die Autorin bzw. den Autor

Xianhai Huang, PhD, Executive Director and Head of Discovery Chemistry at InventisBio Co., Ltd.

Robert G. Aslanian, PhD, Associate Professor of Chemistry and Chair of the Department at New Jersey City University.

Wayne H. Tang, PhD, Executive Director and co-Head of Medicinal Chemistry at Schrödinger Inc.