From DNA Photolesions to Mutations, Skin Cancer and Cell Death
Sprache: Englisch
Verlag: RSC Publishing, 2005
- Hardcover
- Neu
Anbieter: PBShop.store US, Wood Dale, IL, USAPBShop.store US
AbeBooks-Verkäufer/-in seit 7. April 2005
Zustand: Neu
EUR 199,91
Anzahl: 1 verfügbar
In den WarenkorbArtikelbeschreibung vom Verkäufer
New Book. Shipped from UK. Established seller since 2000.
Bestandsnummer des Verkäufers GB-9780854043262
- Titel
- From DNA Photolesions to Mutations, Skin Cancer and Cell Death
- Autor
- Hader, Donat-P
- Verlag
- RSC Publishing
- Veröffentlichungsjahr
- 2005
- Zustand
- New
- Einband
- HRD
- Sprache
- Englisch
- ISBN-10
- 0854043268
- ISBN-13
- 9780854043262
- Artikelgewicht
- 696 Gramm
„Inhaltsangabe“ gehört möglicherweise zu einer anderen Auflage dieses Titels.
Auszug. © Genehmigter Nachdruck. Alle Rechte vorbehalten.
From DNA Photolesions to Mutations, Skin Cancer and Cell Death
By Évelyne Sage, Régen Drouin, Mahmoud RouabhiaThe Royal Society of Chemistry
All rights reserved.
Contents
Chapter 1 UVB and UVA induced formation of photoproducts within cellular DNA Jean Cadet, Thierry Douki, Jean-Pierre Pouget and Jean-Luc Ravanat, 1,
Chapter 2 Chemical sequencing profiles of photosensitized DNA damage R. Jeremy H. Davies, Sharon M. Starrs and Clarke S. Stevenson, 15,
Chapter 3 DNA damage induced by UVA radiation: role in solar mutagenesis Evelyne Sage, Daniel Perdiz, Pál Gróf, Anne Reynaud-Angelin, Thierry Douki, Jean Cadet, Patrick J. Rochette, Nathalie Bastien and Régen Drouin, 33,
Chapter 4 Mutations induced by UV and sunlight Gerd P. Pfeifer, Dong-Hyun Lee, Jung-Hoon Yoon and Young-Hyun You, 49,
Chapter 5 Mechanisms and mutagenic consequences of photoproduct bypass by replicative and DNA damage bypass polymerases John-Stephen Taylor, 57,
Chapter 6 The Ogg1 protein of Saccharomyces cerevisiae: properties and biological functions Serge Boiteux, 93,
Chapter 7 The role of a yeast homologue of the human phosphatase activator hPTPA in the cellular response to oxidative DNA damage Dindial Ramotar, Jocelyn David and Elliot Drobetsky, 103,
Chapter 8 DNA repair in RNA polymerase I transcribed genes Antonio Conconi, Vyacheslav A. Bespalov, Deirdre Fahy and Michael J. Smerdon, 123,
Chapter 9 Global genome nucleotide excision repair: key players and their functions Marcel Volker and Leon H.F. Mullenders, 149,
Chapter 10 Efficient repair of UV-induced DNA damage in terminally differentiated human keratinocytes Dennis H. Oh and Kelvin Yeh, 167,
Chapter 11 Reactivation of UV-damaged viruses and reporter genes in mammalian cells Andrew J. Rainbow, Photini Pitsikas, Colleen Caney, Ihor P. Boszko, Bruce C. McKay and Murray A. Francis, 181,
Chapter 12 Transcription of p53-regulated genes under transcriptional stress: implications for nucleotide excision repair Bruce C. McKay, Cecilia Becerril and Jennifer C. Spronck, 205,
Chapter 13 What a difference a wavelength makes: The role of p53 in nucleotide excision repair of UV-induced DNA damage Julie Desnoyers, Dindial Ramotar, Géraldine Mathonnet, Caroline Léger and Elliot A. Drobetsky, 219,
Chapter 14 p53 and p33ING1: Role in nucleotide excision repair of UV-damaged DNA K-John Cheung Jr. and Gang Li, 233,
Chapter 15 Nuclear and Non-nuclear signals leading to UV-induced apoptosis Momchil D. Vodenicharov and Girish M. Shah, 247,
Chapter 16 Opposing roles of UV-induced apoptosis in early skin cancer Wengeng Zhang and Douglas E. Brash, 269,
Chapter 17 Acquired activation of signalling pathways in skin tumours from DNA repair-deficient xeroderma pigmentosum patients Jean-Claude Ehrhart, Fabien P. Gosselet, Raphaél M. Culerrier and Alain Sarasin, 281,
Chapter 18 Chaos theory and self-organized criticality describe the DNA damage signal transduction network Daniel B. Yarosh, 293,
Subject Index, 307,
CHAPTER 1
UVB and UVA induced formation of photoproducts within cellular DNA
Jean Cadet, Thierry Douki, Jean-Pierre Pouget and Jean-Luc Ravanat
Table of contents
Abstract
1.1 Introduction 3
1.2 Distribution of UVB radiation-induced dimeric
pyrimidime photoproducts within cellular DNA 5
1.3 UVC and UVB-induced formation of monomeric base photoproducts 7
1.4 Damage induced by UVA radiation to cellular DNA 8
1.5 Conclusions 10
References 10
Abstract
Emphasis is placed in this short survey on recent aspects of the photochemistry of cellular DNA that involve both the effects of UVB and UVA radiations. Direct excitation of the purine and pyrimidine bases of DNA is known to mostly generate dimeric pyrimidine photoproducts in oxygen independent photoreactions. Interestingly, the twelve possible dimeric photoproducts at the four main bipyrimidine sites can now be singled out as dinucleoside monophosphates. This is achieved using a specific and sensitive assay that associates high performance liquid chromatography to tandem mass spectrometry (HPLC-MS/MS) operating in the electrospray ionization (ESI) mode. Thus, it was found that UVB irradiation of human monocyte cells gives rise predominantly to cis-syn cyclobutadithymine, thymine-cytosine pyrimidine(6-4) pyrimidone adduct and related cyclobutyl dimer. In contrast the dimeric photoproducts at (di)cytosine sites are generated in very low yields although characteristic tandem mutations of UV-B irradiation are observed at the latter CC sequences. Further, cytosine photohydrate and Dewar valence isomers of the (6-4) photoproducts are at the best minor UV-B photoproducts. Relevant information on UVA-sensitized oxidative damage to cellular DNA was gained from measurements using chromatographic methods and the modified comet assay. Thus, it was shown that 8-oxo-7,8-dihydro-2'-deoxyguanosine is the predominant DNA oxidation product, as mostly, the result of singlet oxygen oxidation. In addition, oxidized pyrimidine bases and DNA strand breaks whose formation involves •OH radical, are produced in much lower yields. Work is in progress to assess the UVA-induced formation of other markers of oxidative stress. These include on the one hand DNA-protein crosslinks and on the other hand DNA adducts with reactive aldehydes that arise from the breakdown of initially generated lipid peroxides.
1.1 Introduction
Solar UV radiation appears to be the main etiological factor responsible for the induction of skin cancers in human population. It is well established that UVB and UVA radiations act mostly on cellular DNA via direct and photosensitized reactions respectively [for earlier reviews, see 1,2]. Precise assessment of the final products of these photoreactions has been hampered for years by the lack of accurate and quantitative methods of measurement. This particularly concerns the individual determination of dimeric pyrimidine photoproducts including cis-syn cyclobutadi-pyrimidines (CPDs), pyrimidine (6-4) pyrimidone photoadducts (6-4PPs) and related valence Dewar isomers (DewarPPs) for which only limited information was available until recently. However, relevant data on the distribution and repair of the three latter classes of photoproducts within the DNA of plasmids, isolated cells and tissues were gained mostly from serological approaches. These include ELISA, RIA and immuno-dot-blot measurements together with immunostaining detection through the availability of monoclonal and polyclonal antibodies. We may also mention the recent development of an immunological method aimed at measuring CPDs and 6-4PPs in the DNA of isolated cells in association with the comet assay. Another suitable method that is receiving major attention is the ligation-mediated polymerase chain reaction (LM-PCR). This allows the mapping within DNA at the nucleotide resolution of dimeric pyrimidine photoproducts and particularly of CPDs, the latter lesions being revealed through the nicking activity of T4 endonuclease V. Thus, it was found that methylation of cytosine residues in 5'-CCG and 5'-TCG sequences leads to a 10-fold increase in the UVB formation of CPDs. Interestingly the latter lesions were found to constitute major p53 mutation hot spots in mouse skin tumors. It was also shown that accumulation of dimeric DNA photoproducts takes place at the same locations of the p53 gene in...
„Über diesen Titel“ gehört möglicherweise zu einer anderen Auflage dieses Titels.
PBShop.store US
Wood Dale, IL, USA
AbeBooks-Verkäufer/-in seit 7. April 2005
Versandkosten innerhalb von USA
| Artikel | 7 bis 14 Werktage | 7 bis 14 Werktage |
|---|---|---|
| Erster Artikel | EUR 0,00 | EUR 0,00 |
Zahlungsarten
Shop-Beschreibung
We first started out as “The Paperback Exchange,” a chain of physical bookstores where we would part exchange your beloved books for new stories to transport you to faraway places. However, as shopping started to evolve to online shops and marketplaces, we bid our stores goodbye to become “PBShop.” This transition has only allowed us to blossom as we now ship thousands of titles to book lovers across the globe. We pride ourselves in being a community of local book lovers which allows our passion and devotion to shine in everything we do. In 2020 we not only celebrated our 20th birthday but our 1st birthday as being completely employee owned after becoming an E.O.T in September 2019. We are proud to be different and embrace standing apart on a book mountain by working from a virtual inventory which allows us to provide thousands of books that may be difficult to get for your bookshelf or your studies. Working with a number of different suppliers allows us to explore other avenues such as puzzles, sheet music and even stationery so we really do have something for everyone. Life is about being versatile in all realms of existence. If this is your first visit or you are a returning customer, we would like to welcome you to the PBShop family, for there is no friend as loyal as a book. We are a company who put our customers at the centre of everything we do as we understand the importance of reading because once you learn to read, you will forever be free. There are a whole lot of things in this world of ours that we are yet to explore, which is why we will forever inspire curious minds.…
Spezialisierung
Hardbacks, PaperbacksUnternehmensdaten der Verkäuferin bzw. des Verkäufers
Pbshop.co.uk Ltd
Unit 22 Horcott Industrial Estate, Horcott Road
Fairford, Vereinigtes Königreich GL7 4BX
Verkaufsbedingungen
Returns Policy
We ask all customers to contact us for authorisation should they wish to return their order. Orders returned without authorisation may not be credited.
If you wish to return, please contact us within 14 days of receiving your order to obtain authorisation.
Returns requested beyond this time will not be authorised.
Our team will provide full instructions on how to return your order and once received our returns department will process your refund.
Please note the cost to return any unwanted order to us is borne by the buyer.
Should your order arrive damaged, not as advertised or faulty, we must be advised of this within 14 days of delivery. Please contact us so we can find the best solution for you.
Our Customer Care Team can be contacted via emailing paperback-us@paperbackshop.co.uk, or by calling our UK Office on +441285 712 917. We are available 9:00am till 5:30pm GMT weekdays and 9:00am till 1:00pm GMT on Saturdays.Returns Policy
We ask all customers to contact us for authorisation should they wish to return their order. Orders returned without authorisation may not be credited.
If you wish to return, please contact us within 14 days of receiving your order to obtain authorisation.
Returns requested beyond this time will not be authorised.
Our team will provide full instructions on how to return your order and once received our returns department will process your refund.
Please note the cost to return any unwanted order to us is borne by the buyer.
Should your order arrive damaged, not as advertised or faulty, we must be advised of this within 14 days of delivery. Please contact us so we can find the best solution for you.
Our Customer Care Team can be contacted via emailing paperback-us@paperbackshop.co.uk, or by calling our UK Office on +441285 712 917. We are available 9:00am till 5:30pm GMT weekdays and 9:00am till 1:00pm GMT on Saturdays.
Widerrufsrecht
Wenn Sie Verbraucher sind, können Sie gemäß den folgenden Bestimmungen vom Vertrag zurücktreten. Verbraucher ist jede natürliche Person, die zu Zwecken handelt, die nicht ihrer kaufmännischen, gewerblichen, künstlerischen oder beruflichen Tätigkeit zugerechnet werden können.
Informationen zum Widerrufsrecht
Gesetzliches Widerrufsrecht
Sie haben das Recht, den Vertrag innerhalb von 14 Tagen ohne Angabe von Gründen zu widerrufen.
Die Widerrufsfrist beträgt 14 Tage ab dem Tag, an dem Sie oder ein von Ihnen benannter Dritter, der nicht der Transporteur ist, die letzte Ware oder den letzten Posten oder das letzte Exemplar in Besitz genommen hat.
Um das Widerrufsrecht auszuüben, füllen Sie auf unserer Website unter „Meine Einkäufe" in „Mein Nutzerkonto" eine eindeutige Erklärung elektronisch aus und senden Sie sie ab. Wir werden Ihnen unverzüglich eine Bestätigung über den Eingang eines solchen Widerrufs auf einem dauerhaften Datenträger (z. B. per E-Mail) übermitteln.
Um die Widerrufsfrist einzuhalten, reicht es aus, dass Sie Ihre Mitteilung über die Ausübung des Widerrufsrechts vor Ablauf der Widerrufsfrist absenden.
Auswirkungen des Widerrufs
Wenn Sie diesen Vertrag widerrufen, erstatten wir Ihnen alle Zahlungen, die wir von Ihnen erhalten haben, einschließlich der Lieferkosten (mit Ausnahme der zusätzlichen Kosten, die entstehen, wenn Sie eine andere Art der Lieferung als die von uns angebotene günstigste Standardlieferung gewählt haben).
Wir können einen Abzug von der Rückerstattung für den Wertverlust der gelieferten Waren vornehmen, wenn der Verlust auf eine unnötige Behandlung durch Sie zurückzuführen ist.
Wir werden die Rückerstattung unverzüglich und nicht später als 14 Tage nach dem Tag vornehmen, an dem wir über Ihre Entscheidung, diesen Vertrag zu widerrufen, informiert wurden.
Für die Rückerstattung verwenden wir dasselbe Zahlungsmittel, das Sie für die ursprüngliche Transaktion verwendet haben, es sei denn, Sie haben ausdrücklich etwas anderes vereinbart; in keinem Fall werden Ihnen aufgrund einer solchen Rückerstattung Gebühren berechnet.
Wir können die Rückzahlung verweigern, bis wir die Waren wieder zurückerhalten haben oder Sie den Nachweis erbracht haben, dass Sie die Waren zurückgesandt haben, je nachdem, was eher eintritt.
Sie müssen die Waren unverzüglich und in jedem Fall spätestens 14 Tage ab dem Tag, an dem Sie uns über den Widerruf dieses Vertrags unterrichten, an PBShop.store US, Springfield Gardens, New York, U.S.A., +44 1285 712917, zurücksenden oder übergeben. Die Frist ist eingehalten, wenn Sie die Ware vor Ablauf der Frist von 14 Tagen zurücksenden. Sie müssen die direkten Kosten der Rücksendung der Waren tragen. Sie haften nur für einen etwaigen Wertverlust der Waren, der auf eine Behandlung zurückzuführen ist, die nicht zur Prüfung der Art, Eigenschaften und Funktionsweise der Waren erforderlich ist.
Ausnahmen vom Widerrufsrecht
Das Widerrufsrecht gilt nicht für:
- Die Lieferung von Zeitungen, Zeitschriften oder Magazinen mit Ausnahme von Abonnementverträgen; und
- Die Lieferung digitaler Inhalte, die nicht auf einem physischen Medium (z. B. auf einer CD oder DVD) geliefert werden, wenn Sie bei Ihrer Bestellung akzeptiert haben, dass wir mit der Lieferung beginnen können und dass Sie nach Beginn der Lieferung den Vertrag nicht mehr widerrufen können.
Versandbedingungen
Books are shipped from our US or UK warehouses. Delivery estimates allow for delivery from either location.