Direct Mechanisms in Cholesterol Modulation of Protein Function

Rosenhouse-Dantsker, Avia|Bukiya, Anna N.

ISBN 10: 3030142647 / ISBN 13: 9783030142643

Verlag: Springer International Publishing, 2019

Beschreibung

Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Very timely topic as cholesterol, increasingly, has been implicated as a major regulator of protein functionContributors are well-known experts in their fields and provide international perspectiveResearch will be invaluable across s.

Bestandsnummer des Verkäufers 268493078

Bibliografische Details

• Titel: Direct Mechanisms in Cholesterol Modulation of Protein Function
• Verlag: Springer International Publishing
• Erscheinungsjahr: 2019
• Sprache: Englisch
• ISBN-10: 3030142647
• ISBN-13: 9783030142643
• Einband: Gebunden
• Zustand: New
• Verkäuferkataloge:
  • Mathematik/Naturwissenschaften/Technik/Medizin

Über diesen Titel

Inhaltsangabe

In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis.  

Direct Mechanisms in Cholesterol Modulation of Protein Function offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmembrane and soluble protein domains. In the second part of the book, examples of cholesterol binding sites and consequences of specific cholesterol recognition for protein function are presented for G protein-coupled receptors, ion channels and cholesterol-transporting proteins.

The book is valuable for undergraduate and graduate students in biochemistry and nutrition, as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.