Endotoxins: Structure, Function and Recognition

. Ed(s): Wang, Xiaoyuan; Quinn, Peter J.

ISBN 10: 9400732678 / ISBN 13: 9789400732674

Verlag: Springer, 2012

Beschreibung

Endotoxins explores the mechanism behind whole-body inflammation and sepsis by synthesizing the leading research in the field. The biosynthesis, genetic constitution, and structure of endotoxins are presented, in addition to their interaction with host cells. Editor(s): Wang, Xiaoyuan; Quinn, Peter J. Series: Subcellular Biochemistry. Num Pages: 432 pages, biography. BIC Classification: MJCJ; MJCM; MMFM; MMG. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 25. Weight in Grams: 664. . 2012. 2010th Edition. paperback. . . . . Books ship from the US and Ireland.

Bestandsnummer des Verkäufers V9789400732674

Bibliografische Details

• Titel: Endotoxins: Structure, Function and Recognition
• Verlag: Springer
• Erscheinungsjahr: 2012
• Sprache: Englisch
• ISBN-10: 9400732678
• ISBN-13: 9789400732674
• Einband: Softcover
• Zustand: New

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Von der hinteren Coverseite

Endotoxins are potentially toxic compounds produced by Gram-negative bacteria including some pathogens. Unlike exotoxins, which are secreted in soluble form by live bacteria, endotoxins are comprised of structural components of bacteria. Endotoxins can cause a whole-body inflammatory state, sepsis, leading to low blood pressure, multiple organ dysfunction syndrome and death.This book brings together contributions from researchers in the forefront of these subjects. It is divided into two sections. The first deals with how endotoxins are synthesized and end up on the bacterial surface. The second discussed how endotoxins activate TLR4 and, in turn, how TLR4 generates the molecular signals leading to infectious and inflammatory diseases.The way endotoxins interact with the host cells is fundamental to understanding the mechanism of sepsis, and recent research on these aspects of endotoxins has served to illuminate previously undescribed functions of the innate immune system. This volume presents a description of endotoxins according to their genetic constitution, structure, function and mode of interaction with host cells.