Providing a wealth of insights drawn from the experience of groundbreaking researchers working in the field, this Second Edition of a landmark volume brings preclinical and clinical studies of Filgrastim (r-metHuG-CSF) up to date with completely revised and expanded discussions of its biology, biochemistry, structure, pharmacology, clinical applications, and pharmacoeconomics.
Explores how Filgrastim reduces infectious complications in the management of cancer, AIDS, severe chronic neutropenia, neutropenia associated with nonmalignant autoimmune diseases, non-neutropenic infections, lymphoma, leukemia, diabetic foot infection, and more!
Now enhanced with 13 new chapters, Filgrastim (r-metHuG-CSF) in Clinical Practice, Second Edition features novel research as well as provocative and enhanced information on
pharmacokinetic-pharmacodynamic modeling to delineate concentration-response relationships
Filgrastim as treatment or prophylaxis for decreasing infectious episodes, intensifying immunosuppresive therapy, and mobilizing progenitor stem cells
improving granulocyte collection yields from normal donors and neutrophil transfusions in recipients of such products
the potential of peripheral blood progenitor cell (PBPC) transplantation in diseases, such as rheumatoid arthritis
maintaining optimal chemotherapy intensity in situations where dose reduction or delay is necessary
combining Filgrastim with various cytokines, including granulocyte-macrophage colony-stimulating factor, stem-cell factor, rHuSCF, IL-3, and erythropoietin
Filgrastim's toxicity profile, daily aspects of administration, economic impact, and effect on patients' quality of life
and much more!
Containing over 1650 references-more than 600 new to this edition!-this truly outstanding Second Edition continues to furnish unparalleled coverage of the subject matter for oncologists, hematologists, infectious disease specialists, immunologists, radiotherapists, oncological nurses, and graduate and medical school students in these disciplines."International praise for the first edition... skillfully edited bypioneers in the field. "-Annals of Oncology "a concise and easily accessible reference source. Most of the clinical chapters have been written by workers who participated in many of the key studies with Filgrastim performed to date and are a useful chronicle of its clinical development. well written and referenced. "-Cancer Forum "provide[s] the clinician with important basic information.useful. "-British Journal of Cancer and the Second Edition... "an excellent review on Filgrastim. In addition to the presentation of the drug it gives a didactic description of the diseases in which the drug has been used. It outlines also their treatment strategy with the inclusion of Filgrastim into the treatment protocols. The monograph can be recommended for clinicians, residents, and even for medical students interested in oncology. "-Haematologia
