Formulation and Evaluation of Albendazole Tablet: Gastroretentive Floating Tablet of Albendazole

Chaurasia, Sandhya,Sharma, Anshuli,Vasireddy, Suneel kumar

ISBN 10: 3659192929 / ISBN 13: 9783659192920

Verlag: LAP LAMBERT Academic Publishing, 2012

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Inhaltsangabe:

The objective of this research work was to formulate and evaluate the floating drug delivery system containing Albendazole, an anthelmintic drug, using different polymers and to optimize the best formulation. Different excipients were tested for their compatibility with Albendazole by the FTIR studies. Present study has demonstrated the successful utilization of technique of FT IR to assesst he compatibility of Albendazole with the excipients used in the development of floating drug delivery system of Albendazole. Based on the results of FT-IR studies, majority of the excipients were found to be compatible with Albendazole which were then used in the preparation of Albendazole floating tablets. Albendazole tablets were prepared by wet granulation technique using HPMC, HPMC K4M and chitosan as polymers, stearic acid, citric acid, lactose and gas generating agent such as sodium bicarbonate were taken as independent variables. It was then evaluated by using USP-II (Paddle) apparatus containing 0.1 N HCl as a dissolution media. The release mechanisms of Albendazole from floating tablet were evaluated by the n value of Krosmeyer Peppas model.

Über die Autorin bzw. den Autor: Sandhya Chaurasia completed her M pharmacy from Rajiv Gandhi Technical University Bhopal (M.P.)

Bibliografische Details

Titel: Formulation and Evaluation of Albendazole ...
Verlag: LAP LAMBERT Academic Publishing
Erscheinungsdatum: 2012
Einband: paperback
Zustand: Very Good