Formulation and evaluation of Aceclofenac transdermal gels

Kirankumar Suthar (u. a.)

ISBN 10: 365964305X / ISBN 13: 9783659643057

Verlag: LAP LAMBERT Academic Publishing, 2015

Formulation and evaluation of Aceclofenac transdermal gels | Kirankumar Suthar (u. a.) | Taschenbuch | 108 S. | Englisch | 2015 | LAP LAMBERT Academic Publishing | EAN 9783659643057 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu. Bestandsnummer des Verkäufers 104453592

Inhaltsangabe:

Use of NSAIDs by systemic route may invoke the side effects as high dosages are required. By oral administration, the patient may suffer the side effects like gastrointestinal ulceration and intolerance, due to acidic nature of NSAIDs. Also by systemic route drug may be metabolized in liver. So drug loss will take place. Aceclofenac is a non steroidal anti-inflammatory drug which is a phenyl acetic acid derivative with effective anti-inflammatory and analgesic properties. It is a selective COX-2 inhibitor, mainly used for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Transdermal drug administration was selected for Aceclofenac to avoid first pass metabolism in liver, to overcome the gastrointestinal irritation as drug is acidic in nature and to localize the drug at the disease site by the transdermal delivery of drug.

Über die Autorin bzw. den Autor: The Aceclofenac will be formulated for its transdermal delivery in the gel form. Following objects were set for the project:1.Preparation and characterization of Aceclofenac gel, using Carbopol 934P NF gel base.2.Preparation and characterization of Aceclofenac gel, using Poloxamer 407 gel base.3.Effect of penetration enhancers on the release of it.

Bibliografische Details

Titel: Formulation and evaluation of Aceclofenac ...
Verlag: LAP LAMBERT Academic Publishing
Erscheinungsdatum: 2015
Einband: Taschenbuch
Zustand: Neu