Functional Tissue Engineering.

F. et al Guilak

ISBN 10: 0387955534 / ISBN 13: 9780387955537

Verlag: New York, NY, U.S.A. Springer-Verlag New York, Incorporated, 2003

Beschreibung

Gebraucht - Gut Zustand: Gut, Mängelexemplar, XVI, 426 p. 133 illus. About this book: The goal of tissue engineering is to repair or replace tissues and organs by delivering implanted cells, scaffolds, DNA, proteins, and/or protein fragments at surgery. Tissue engineering merges aspects of engineering and biology, and many rapid achievements in this field have arisen in part from significant advances in cell and molecular biology. Functional Tissue Engineering addresses the key issues in repairing and replacing load-bearing structures effectively. What are the thresholds of force, stress, and strain that normal tissues transmit or encounter? What are the mechanical properties of these tissues when subjected to expected in vivo stresses and strains, as well as under failure conditions? Do tissue engineered repairs and replacements need to exactly duplicate the structure and function of the normal tissue or organ? When developing these implants in culture, how do physical factors such as mechanical stress regulate cell behavior in bioreactors as compared to signals experienced in vivo? And finally, can tissue engineers mechanically stimulate these implants before surgery to produce a better repair outcome? Chapters written by well-known researchers discuss these matters and provide guidelines and a summary of the current state of technology. Written for graduate students; researchers; biotech industrial/pharmacologist.

Bestandsnummer des Verkäufers 17030

Bibliografische Details

• Titel: Functional Tissue Engineering.
• Verlag: New York, NY, U.S.A. Springer-Verlag New York, Incorporated
• Erscheinungsjahr: 2003
• Sprache: Englisch
• ISBN-10: 0387955534
• ISBN-13: 9780387955537
• Einband: Gebunden
• Zustand: Gut

Über diesen Titel

Inhaltsangabe

-Softcover reprint of a successful hardcover reference (370 copies sold)

-Price to be accessible to the rapidly increasing population of students and investigators in the field of tissue engineering

-Chapters written by well-known researchers discuss issues in functional tissue engineering as well as provide guidelines and a summary of the current state of technology

Von der hinteren Coverseite

The goal of "tissue engineering" is to repair or replace tissues and organs by delivering implanted cells, scaffolds, DNA, proteins, and/or protein fragments at surgery. Tissue engineering merges aspects of engineering and biology, and many rapid achievements in this field have arisen in part from significant advances in cell and molecular biology.

Despite its early successes, however, tissue engineers have faced challenges in repairing or replacing tissues that serve a predominantly biomechanical function. This book addresses and discusses a number of issues that need to be addressed in order for tissue engineers to effectively repair or replace these load-bearing structures. What are the thresholds of force, stress, and strain that normal tissues transmit or encounter? What are the mechanical properties of these tissues when subjected to expected in vivo stresses and strains, as well as under failure conditions? Which of these properties should a tissue engineer insist upon incorporating into the design? Do tissue engineered repairs and replacements need to exactly duplicate the structure and function of the normal tissue or organ in order to be successful? When developing these implants in culture, how do physical factors such as mechanical stress regulate cell behavior in bioreactors as compared to signals experienced in vivo? And finally, can tissue engineers mechanically stimulate these implants before surgery to produce a better repair outcome?

Chapters written by well-known researchers discuss these matters and provide guidelines and a summary of the current state of technology in functional tissue engineering. The book will be useful to students and researchers as it will increase awareness among tissue engineers of the importance of restoring "function" when engineering tissue constructs, and identifying the critical structural and mechanical requirements needed for each construct. It will also providean invaluable source of information to help tissue engineers incorporate these functional criteria into the design, manufacture, and optimization of tissue engineered products. Finally it serves as a reference and teaching text for the rapidly increasing population of students and investigators in the field of tissue engineering.