Gastrointestinal Malignancies

This book is a practical guide on how best to incorporate advanced radiation therapy techniques into the multimodality treatment of a wide range of gastrointestinal tumors, including esophageal cancer, gastric cancer, hepatobiliary malignancies (primary and metastatic liver tumors, intrahepatic, perihilar, and extrahepatic cholangiocarcinomas, and gallbladder cancer), pancreatic cancer, colorectal cancer, and carcinoma of the anal canal. Practical considerations when treating patients with external beam radiation therapy, intensity-modulated radiation therapy, particle therapy, and stereotactic body radiation therapy are clearly explained. Detailed attention is devoted to the safety and efficacy of radiotherapy in combination with current and emerging systemic therapies (chemotherapy, immunotherapy, and biologic agents), surgery, and ablative therapy, and the advantages and disadvantages of alternative treatment approaches for different tumor types are carefully evaluated. The bookwill benefit radiation oncologists, medical and surgical oncologists, medical physicists, medical dosimetrists, and other oncology professionals.

Dr. Suzanne M. Russo is an Associate Professor at Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Her research and clinical interests include the multidisciplinary treatment of cancers of the esophagus, stomach, liver, pancreas, bile duct, rectum, colon, and anus, as well as drug–radiation interactions and application of technology in cancer treatment.  Dr. Russo is experienced with a wide range of advanced radiation therapy techniques. She is a member of the ECOG-ACRIN Gastrointestinal Committee and the American College of Radiology Appropriateness Criteria Expert Panel for Rectal Cancer. Dr. Russo has been principal investigator/co-investigator in multiple investigator-initiated clinical trials studying drug–radiation interactions in patients with gastrointestinal malignancies and has served as institutional investigator for cooperative group trials dedicated to finding more effective treatments for these malignancies. She has published over 65 peer-reviewed papers as well as numerous textbook chapters and is an editorial board member and reviewer for various oncology journals.

Dr. Sarah Hoffe is the Section Head of GI Radiation Oncology at Moffitt Cancer Center, Tampa, Florida, USA, and an Associate Member at Moffitt, as well as Associate Professor in the University of South Florida Morsani College Of Medicine’s Department of Oncologic Sciences. Her research and clinical interests include cancers of the esophagus, stomach, liver, pancreas, bile duct, rectum, colon, and anus, as well as neuroendocrine cancers. Dr. Hoffe has experience with diverse advanced radiation therapy techniques. At Moffitt, she works closely with her multidisciplinary colleagues in GI surgery, medical oncology, gastroenterology, radiology, and pathology to develop new treatments for patients with GI cancers. She is the past Director of eContouring at ASTRO. She is on the advisory board for the journals Contemporary Radiation Oncology and the editorial board of Cancer Control. She is a member of the GI ASCO program committee and is Moffitt Cancer Center’s representative on the NCCN panel on Cancers of the Colon, Rectum, and Anus. She has authored over 90 publications in peer-reviewed journals.

Dr. Edward Kim is an Associate Professor and disease site lead for gastrointestinal cancers in the Department of Radiation Oncology, University of Washington, USA. He specializes in the treatment of gastrointestinal cancers and is experienced with intensity-modulated radiation therapy (IMRT), three-dimensional conformal radiation therapy (3D-CRT), brachytherapy, proton radiotherapy, neutron therapy, stereotactic body radiation therapy (SBRT), image-guided radiation therapy (IGRT), and intraoperative radiotherapy. He chairs the Radiological Society of North America Radiation Oncology Scientific Program Committee and is the author of numerous publications in peer-reviewed journals and textbooks.