This handbook is intended to serve as a reference text on statistical methods for randomized controlled trials. It can be used as a textbook for a graduate course in statistical methods for randomized controlled trials as well as a reference for those involved in the design, monitoring and analysis of randomized controlled trials.

�ber die Autorin bzw. den Autor

KyungMann Kim is Professor of Biostatistics and Statistics and Director of Clinical Trials Program, Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison. He is a former associate editor of Biometrics and an elected Fellow of the American Statistical Association, the Society for Clinical Trials, and the American Association for Advancement of Science.

Frank Bretz is a Distinguished Quantitative Research Scientist at Novartis. He is also an Adjunct Professor at the Hannover Medical School (Germany) and the Medical University Vienna (Austria). He is a former editor-in-chief of Statistics in Biopharmaceutical Research. a Fellow of the American Statistical Association, and a recipient of the Susanne-Dahms-Medal from the German Region of the International Biometric Society.

Ying Kuen (Ken) Cheung is Professor of Biostatistics and Associate Dean for Faculty in the Mailman School of Public Health at Columbia University. He is a recipient of the IBM Faculty Award on Big Data and Analytics. He is a Fellow of the American Statistical Association and a Fellow of the New York Academy of Medicine.

Lisa Hampson is a Director in Statistical Methodology at Novartis.

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