WITH INCREASING USE OF LIGAND–BINDING ASSAYS (LBAS) IN THE PHARMACEUTICAL INDUSTRY, THE NEED TO CRITICALLY EVALUATE TECHNICAL AND REGULATORY ISSUES RELATED TO THE USE OF THESE TECHNOLOGIES HAS INCREASED GREATLY. THIS BOOK FILLS THAT VOID AND PROVIDES A REFERENCE TEXT COVERING CRITICAL ASPECTS OF THE DEVELOPMENT, VALIDATION, AND IMPLEMENTATION OF LBAS IN THE DRUG DEVELOPMENT FIELD. IT INCLUDES: IMMUNOCHEMISTRY AND PROTEIN CHEMISTRY, METHOD DEVELOPMENT, VALIDATION, STATISTICS, SOFTWARE, REGULATORY ISSUES, AND APPLICATIONS TO IMMUNOGENICITY AND BIOMARKERS. THIS IS A KEY RESOURCE FOR BIOANALYTICAL PERSONNEL, LABORATORY ANALYSTS, AND CLINICAL AND REGULATORY PHARMACOLOGISTS.

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"Ligand-Binding Assays, edited by Masood Kahn and John Findlay offers a comprehensive, in depth description of all aspects of the subject. The editors are directly involved in the ligand-binding assay field and individual chapters are written by experts with a thorough understanding of the specific topics. The book is easy to read, clear and well illustrated. The emphasis is on biologicals rather than small molecules and this reflects the current application of many of the procedures covered. There is a good overview of assay validation, and this book is highly recommended for those with an interest in the topic." -Robin Thorpe, PhD FRCPath, National Institute for Biological Standards and Control "This book is a collection of valuable articles describing these assays in some detail, both from a historical perspective ..., but also regarding the new developments in the field, such as new technologies to support drug development ... and pharmacokinetic research." (ChemMedChem, July 2010)

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