Mathematical Methods for Protein Structure Anaylysis and Design : C.I.M.E. Summer School, Martinal Franca, Italy, July 9-15, 2000 : Advanced Lectures

Guerra, Concettina (EDT); Istrail, Sorin (EDT)

ISBN 10: 3540401040 / ISBN 13: 9783540401049

Verlag: Springer, 2003

Beschreibung

Bestandsnummer des Verkäufers 5907014-n

Bibliografische Details

• Titel: Mathematical Methods for Protein Structure Anaylysis and Design : C.I.M.E. Summer School, Martinal Franca, Italy, July 9-15, 2000 : Advanced Lectures
• Verlag: Springer
• Erscheinungsjahr: 2003
• Sprache: Englisch
• ISBN-10: 3540401040
• ISBN-13: 9783540401049
• Einband: Softcover
• Zustand: New

Über diesen Titel

Inhaltsangabe

The revised lectures presented in this volume are based on a course given by leading scholars at the C.I.M.E. Summer School held in Martina Franca, Italy, in July 2000. The 11 revised chapters presented were carefully revised and cross-reviewed in order to provide competent coverage of mathematical methods for protein structure analysis and design. The topics addressed pinpoint major issues arising in the development and analysis of models, algorithms, and software tools devoted to the structure of proteins, all of which play crucial roles in structural genomics and proteomics.

Reseña del editor

The papers collected in this volume reproduce contributions by leading sch- arstoaninternationalschoolandworkshopwhichwasorganizedandheldwith thegoaloftakinga snapshotofadiscipline undertumultuous growth. Indeed, the area of protein folding, docking and alignment is developing in response to needs for a mix of heterogeneous expertise spanning biology, chemistry, mathematics, computer science, and statistics, among others. Some of the problems encountered in this area are not only important for the scienti?c challenges they pose, but also for the opportunities they disclose intermsofmedicalandindustrialexploitation. Atypicalexampleiso?eredby protein-drug interaction (docking), a problem posing daunting computational problems at the crossroads of geometry, physics and chemistry, and, at the same time, a problem with unimaginable implications for the pharmacopoeia of the future. The schoolfocused on problems posed by the study of the mechanisms - hind protein folding, and explored di?erent ways of attacking these problems under objective evaluations of the methods. Together with a relatively small core of consolidated knowledge and tools, important re?ections were brought to this e?ort by studies in a multitude of directions and approaches. It is obviously impossible to predict which, if any, among these techniques will prove completely successful, but it is precisely the implicit dialectic among them that best conveys the current ?avor of the ?eld. Such unique diversity and richness inspired the format of the meeting, and also explains the slight departure of the present volume from the typical format in this series: the exposition of the current sediment is complemented here by a selection of quali?ed specialized contributions.