The book discusses the role of gut microbiome composition in colorectal cancer progression, linking intestinal inflammation, tumorigenesis and anti-cancer immune responses. Chapters delve into various areas, including the mechanisms of action of probiotics and prebiotics (such as Lactobacillus and Bifidobacterium strains, and fructans and galactans, respectively), functional foods such as α-carotene, β-carotene, lutein, β-cryptoxanthin, fucoxanthin, isothiocyanates, flavonoids, probiotics, fibre and omega-3. Lycopene, β-cryptoxanthin, and fucoxanthin. Dietary phytochemicals such as polyphenols (curcumin, gingerol, ferulic acid (FA) and hydroxytyrosol); alkaloids (piperine, and protopine); terpenoids (artemisinin, and astaxanthin); iridoid glycoside (picroside II, and morroniside); and flavonoid (quercetin) on cancer, immune responses, and the gut microbiome. It examines the interaction and influence of prebiotics and probiotics in colorectal cancer treatment, their use in managing chemotherapy-related gastrointestinal problems, and their potential as adjuvants. The book also investigates how these gut microbes are associated with tumor progression and anti-cancer treatment efficacy. This knowledge can be used to develop biomarkers that predict immunotherapy effectiveness and improve treatment outcomes through modulation.
This book provides a comprehensive update on the latest research and clinical applications in the field, offering valuable insights into the complex interplay between probiotics, the gut microbiome, and colorectal cancer. It serves as an invaluable resource for healthcare professionals, researchers, and students seeking to understand this dynamic area of study.
Prof. Surajit Pathak, Ph.D., is a leading researcher and academic, currently a Professor at Chettinad Academy of Research and Education in Chennai. With a Ph.D. from India (2007) and a post-doctoral journey at renowned institutions like the University of Alabama (USA), University of Padova (Italy), and University of Linkoping (Sweden), his research focuses on microRNAs for early colorectal cancer detection. Prof. Pathak has published various research articles, and he is a member of global research societies. His work continues to shape advancements in cancer research and stem cell biology globally.
Dr. Antara Banerjee, Ph.D., is currently working as an Associate Professor at Chettinad Academy of Research and Education (CARE), Chennai. Dr. Banerjee pursued her post-doctoral research on Cancer Biology and Regenerative Medicine at the University of Padova, Italy, and Linkoping University, Sweden. These works fostered her interest in understanding the role of the mesenchymal niche and extra-cellular vesicles in tissue regeneration and exploring signaling pathways in governing stem cell fate. Dr. Banerjee has edited several books on Stem Cells and Cancer. She is affiliated with professional research bodies and is a member of several international research societies.
Professor Asim K. Duttaroy is a leading expert in nutrition and medical science, renowned for his groundbreaking research in lipid metabolism, cardiovascular health, and chronic disease prevention. He has significantly contributed to understanding how food bioactive compounds impact human health. His pioneering work on the cardio-protective properties of fruits e.g., "the role of fruitflow (tomato extract) and kiwifruit extract in reducing platelet aggregation and blood pressure, has led to international patents. His innovative research continues to influence global health strategies and food-based therapies.
