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Inhaltsangabe: The majority of the inhibition in the brain is mediated by GABA-A receptors. Extrasynaptic GABA-A receptors maintain a mild and continuous inhibition known as tonic inhibition. This study determines whether downregulation of tonic inhibition mediated by extrasynaptic GABA-A receptors is causally linked to the formation and/or maintenance of epilepsy-like activity. If true, it paves way for designing novel strategies to treat epilepsy-like brain states. A selective extrasynaptic GABA-A receptor agonist, Gaboxadol (THIP), was used to enhance tonic inhibition. Gaboxadol is a hypotic and was previously developed by Lundbeck and Merck as an experimental sleep drug. This study details the effect of low concentrations of Gaboxadol on CTZ (cyclothiazide) induced epilepsy-like activity in neuronal cultures. The data herein suggests that tonic inhibition contributes towards maintenance of cellular epilepsy and drugs that activate it could be potential therapeutic agents for pathological states like epilepsy.

Über den Autor: Anar Pitre is a Neuroscience doctoral candidate at Cornell University. She is currently studying the cerebellar control of eye movements and the oculomotor neural integrator. Anar enjoys communicating science and understanding its immediate impact on the society.

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Buchbeschreibung Buchzustand: New. Publisher/Verlag: VDM Verlag Dr. Müller | Evaluation of the effects of Gaboxadol on neuronal hyperactivity | The majority of the inhibition in the brain is mediated by GABA-A receptors. Extrasynaptic GABA-A receptors maintain a mild and continuous inhibition known as tonic inhibition. This study determines whether downregulation of tonic inhibition mediated by extrasynaptic GABA-A receptors is causally linked to the formation and/or maintenance of epilepsy-like activity. If true, it paves way for designing novel strategies to treat epilepsy-like brain states. A selective extrasynaptic GABA-A receptor agonist, Gaboxadol (THIP), was used to enhance tonic inhibition. Gaboxadol is a hypotic and was previously developed by Lundbeck and Merck as an experimental sleep drug. This study details the effect of low concentrations of Gaboxadol on CTZ (cyclothiazide) induced epilepsy-like activity in neuronal cultures. The data herein suggests that tonic inhibition contributes towards maintenance of cellular epilepsy and drugs that activate it could be potential therapeutic agents for pathological states like epilepsy. | Format: Paperback | Language/Sprache: english | 72 pp. Buchnummer des Verkäufers K9783639175196

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Buchbeschreibung VDM Verlag Jul 2009, 2009. Taschenbuch. Buchzustand: Neu. 220x150x4 mm. Neuware - The majority of the inhibition in the brain is mediated by GABA-A receptors. Extrasynaptic GABA-A receptors maintain a mild and continuous inhibition known as tonic inhibition. This study determines whether downregulation of tonic inhibition mediated by extrasynaptic GABA-A receptors is causally linked to the formation and/or maintenance of epilepsy-like activity. If true, it paves way for designing novel strategies to treat epilepsy-like brain states. A selective extrasynaptic GABA-A receptor agonist, Gaboxadol (THIP), was used to enhance tonic inhibition. Gaboxadol is a hypotic and was previously developed by Lundbeck and Merck as an experimental sleep drug. This study details the effect of low concentrations of Gaboxadol on CTZ (cyclothiazide) induced epilepsy-like activity in neuronal cultures. The data herein suggests that tonic inhibition contributes towards maintenance of cellular epilepsy and drugs that activate it could be potential therapeutic agents for pathological states like epilepsy. 72 pp. Englisch. Buchnummer des Verkäufers 9783639175196

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Buchbeschreibung VDM Verlag Jul 2009, 2009. Taschenbuch. Buchzustand: Neu. 220x150x4 mm. This item is printed on demand - Print on Demand Neuware - The majority of the inhibition in the brain is mediated by GABA-A receptors. Extrasynaptic GABA-A receptors maintain a mild and continuous inhibition known as tonic inhibition. This study determines whether downregulation of tonic inhibition mediated by extrasynaptic GABA-A receptors is causally linked to the formation and/or maintenance of epilepsy-like activity. If true, it paves way for designing novel strategies to treat epilepsy-like brain states. A selective extrasynaptic GABA-A receptor agonist, Gaboxadol (THIP), was used to enhance tonic inhibition. Gaboxadol is a hypotic and was previously developed by Lundbeck and Merck as an experimental sleep drug. This study details the effect of low concentrations of Gaboxadol on CTZ (cyclothiazide) induced epilepsy-like activity in neuronal cultures. The data herein suggests that tonic inhibition contributes towards maintenance of cellular epilepsy and drugs that activate it could be potential therapeutic agents for pathological states like epilepsy. 72 pp. Englisch. Buchnummer des Verkäufers 9783639175196

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Buchbeschreibung VDM Verlag Jul 2009, 2009. Taschenbuch. Buchzustand: Neu. 220x150x4 mm. Neuware - The majority of the inhibition in the brain is mediated by GABA-A receptors. Extrasynaptic GABA-A receptors maintain a mild and continuous inhibition known as tonic inhibition. This study determines whether downregulation of tonic inhibition mediated by extrasynaptic GABA-A receptors is causally linked to the formation and/or maintenance of epilepsy-like activity. If true, it paves way for designing novel strategies to treat epilepsy-like brain states. A selective extrasynaptic GABA-A receptor agonist, Gaboxadol (THIP), was used to enhance tonic inhibition. Gaboxadol is a hypotic and was previously developed by Lundbeck and Merck as an experimental sleep drug. This study details the effect of low concentrations of Gaboxadol on CTZ (cyclothiazide) induced epilepsy-like activity in neuronal cultures. The data herein suggests that tonic inhibition contributes towards maintenance of cellular epilepsy and drugs that activate it could be potential therapeutic agents for pathological states like epilepsy. 72 pp. Englisch. Buchnummer des Verkäufers 9783639175196

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Buchbeschreibung VDM Verlag, 2009. Paperback. Buchzustand: New. book. Buchnummer des Verkäufers 3639175190

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Buchbeschreibung VDM Verlag, Russian Federation, 2012. Paperback. Buchzustand: New. 220 x 150 mm. Language: English . Brand New Book. The majority of the inhibition in the brain is mediated by GABA-A receptors. Extrasynaptic GABA-A receptors maintain a mild and continuous inhibition known as tonic inhibition. This study determines whether downregulation of tonic inhibition mediated by extrasynaptic GABA-A receptors is causally linked to the formation and/or maintenance of epilepsy-like activity. If true, it paves way for designing novel strategies to treat epilepsy-like brain states. A selective extrasynaptic GABA-A receptor agonist, Gaboxadol (THIP), was used to enhance tonic inhibition. Gaboxadol is a hypotic and was previously developed by Lundbeck and Merck as an experimental sleep drug. This study details the effect of low concentrations of Gaboxadol on CTZ (cyclothiazide) induced epilepsy-like activity in neuronal cultures. The data herein suggests that tonic inhibition contributes towards maintenance of cellular epilepsy and drugs that activate it could be potential therapeutic agents for pathological states like epilepsy. This book was created using print-on-demand technology. Buchnummer des Verkäufers KNV9783639175196

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