Molecular Mechanisms of Cancer

Georg F. Weber

ISBN 10: 1402060157 / ISBN 13: 9781402060151

Verlag: Springer Netherlands, Springer Netherlands Sep 2007, 2007

Beschreibung

Neuware -Cancer may constitute the most extensively studied functions constitute a second line of defense that disease entity of our time. Nevertheless, our com- protects against transforming defects in oncogenes prehension of the cellular and molecular pathology or tumor-suppressor genes and are here considered of malignant transformation is incomplete. In view as metasuppressor genes. Advances in the molecular of the diverse clinical presentations of various explanations of growth dysregulation, metastasis malignancies, doubts may be raised as to whether it formation, extension of life span, and loss of ma- is appropriate to refer to cancer as one group of dis- tenance of genomic and epigenetic integrity in ease states. The notion of malignant tumors as a cancer suggest models for their causal connection. pathologic and pathophysiologic class of conditions The mechanisms of growth control, senescence, and begs the question for defining criteria that charac- anchorage dependence are linked on the molecular terize all malignant growths, regardless of their tis- level (Chapter 8). In cells that are not fully differ- sue of origin. Toward this goal, the recognition that tiated, the overactivation of oncogene pathways tumor development is caused by the dysregulation also induces the expression of metastasis genes. of growth-controlling genes (oncogenes and tumor- Telomerase, the enzyme that prevents cell sen- suppressor genes) has advanced our mechanistic cence, is expressed in these precursor cells and may understanding of oncology (Chapter 3). However, be further activated by growth factor signaling.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 660 pp. Englisch.

Bestandsnummer des Verkäufers 9781402060151

Bibliografische Details

• Titel: Molecular Mechanisms of Cancer
• Verlag: Springer Netherlands, Springer Netherlands Sep 2007
• Erscheinungsjahr: 2007
• Sprache: Englisch
• ISBN-10: 1402060157
• ISBN-13: 9781402060151
• Einband: Buch
• Zustand: Neu

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Inhaltsangabe

Cancer may constitute the most extensively studied functions constitute a second line of defense that disease entity of our time. Nevertheless, our com- protects against transforming defects in oncogenes prehension of the cellular and molecular pathology or tumor-suppressor genes and are here considered of malignant transformation is incomplete. In view as metasuppressor genes. Advances in the molecular of the diverse clinical presentations of various explanations of growth dysregulation, metastasis malignancies, doubts may be raised as to whether it formation, extension of life span, and loss of ma- is appropriate to refer to cancer as one group of dis- tenance of genomic and epigenetic integrity in ease states. The notion of malignant tumors as a cancer suggest models for their causal connection. pathologic and pathophysiologic class of conditions The mechanisms of growth control, senescence, and begs the question for defining criteria that charac- anchorage dependence are linked on the molecular terize all malignant growths, regardless of their tis- level (Chapter 8). In cells that are not fully differ- sue of origin. Toward this goal, the recognition that tiated, the overactivation of oncogene pathways tumor development is caused by the dysregulation also induces the expression of metastasis genes. of growth-controlling genes (oncogenes and tumor- Telomerase, the enzyme that prevents cell sen- suppressor genes) has advanced our mechanistic cence, is expressed in these precursor cells and may understanding of oncology (Chapter 3). However, be further activated by growth factor signaling.

Críticas

From the reviews:

“The book under review is definitely the best book on Molecular Biology of Cancer. ... It is very well written, clear, with several examples and of easy comprehension. I suggest this book to you if you are interested in to study all the tricks of the molecular mechanisms of cancer. ... The books is a necessary reading for all medical and biological students interested in Cancer and it will become the reference on the subject.” (Philosophy, Religion and Science Book Reviews, bookinspections.wordpress.com, December, 2013)