Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnbosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations they contain. But mutation detection is time-consuming and expensive. This volume offers the latest tried and tested protocols for a range of detection methods, from the labs of the leading researchers in the field.

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This book will be useful to laboratory workers in both biolgoy and medicine. It provides practical guidance on tested protocols covering a range of detection methods, including both scanning mode, used for unknown mutations, and the diagnostic mode which tests for know mutations. This practical manual is a welcomed addition to this well-known series. (ASLIB Book Guide, Vol.63, no.7)

'...will provide a valuable resource both for those new to the area and for more experienced mutation detectives...' (Trends in Genetics vol.15, no.1)

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